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Volume 23, Issue 3 (7-2025)                   Int J Radiat Res 2025, 23(3): 715-720 | Back to browse issues page

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Boroumand M, Azmoonfar R, MadadiZadeh F, Saber K, Hamzian N. Dosimetric comparison of acute skin complications following conventional and hypofractionated radiotherapy in breast cancer patients. Int J Radiat Res 2025; 23 (3) :715-720
URL: http://ijrr.com/article-1-6655-en.html
Dosimetric comparison of acute skin complications following conventional and hypofractionated radiotherapy in breast cancer patients
M.A. Boroumand , R. Azmoonfar , F. MadadiZadeh , K. Saber , N. Hamzian
Department of Medical Physics, School of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran , korosh.iut@gmail.com
Abstract:   (265 Views)
Background: Radiation therapy is one of the most important methods of breast cancer treatment that can cause complications that affect the patient's quality of life. The aim of this study was a dosimetric comparison of skin complications after hypofractionated radiotherapy (HFRT) and conventional fractionated radiotherapy (CFRT) in breast cancer patients. Materials and Methods: In this cross-sectional study between November 2021 and July 2022, 55 patients were reviewed. Thirty-six patients received CFRT (50Gy in 25 fractions), and 19 patients received HFRT (42. 5Gy in 16 fractions). Skin complications during treatment and 40 days after radiotherapy were evaluated and compared for these two procedures. Results: The incidence of grade 1, 2, and 3 skin complications up to 40 days after CFRT was 100%, 88.8%, and 22.2%, respectively; also, in HFRT, the incidence of grade 1, 2, and 3 skin complications was 89.4%, 36.8%, and zero, respectively. The results show that the incidence of skin complications is significantly higher with the CFRT than with the HFRT (P<0.05). Conclusion: In this clinical study, both in terms of complications and dosimetry, it was shown that patients undergoing radiation therapy with the hypofractionation technique had fewer skin complications compared to those treated with the conventional technique.
Keywords: Breast cancer, radiotherapy, dermatitis.
Full-Text [PDF 747 kb]   (89 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Narwariya A, Dhakar M, Jatav J, et al. (2022) Comparative study of hypo-fractionated radiotherapy versus conventional radiotherapy in breast cancer. Cureus, 14(9): e29147. DOI:10.7759/cureus.29147 [DOI:10.7759/cureus.29147]
2. Paraskevi T (2012) Quality of life outcomes in patients with breast cancer. Oncol Rev, 6(1): e2. DOI:10.4081/oncol.2012.e2 [DOI:10.4081/oncol.2012.e2]
3. Ghaderi I, Kaviani A, Fakhrejahani E, et al. (2014) Religious, cultural, and social beliefs of iranian rural women about breast cancer: A qualitative study. Arch Breast Cancer, 1(1): 25-31. DOI:10.19187/abc.20141125-31
4. Bride MBM, Neal L, Dilaveri CA, et al. (2013) Factors associated with surgical decision making in women with early-stage breast cancer: a literature review. J Women's Health, 22(3): 236-42. DOI:10.1089/jwh.2012.3969 [DOI:10.1089/jwh.2012.3969]
5. Amin SM and Faraj K (2023) Estimation of oesophageal surface dose in breast cancer patients undergoing supraclavicular irradiation by thermoluminescent dosimeter (TLD) and treatment planning system (TPS). Int J Radiat Res, 21(4): 647-52. DOI:10.61186/ijrr.21.4.647 [DOI:10.61186/ijrr.21.4.647]
6. Behmadi M, Gholamhosseinian H, Mohammadi M, et al. (2019) Evaluation of breast cancer radiation therapy techniques in outfield organs of rando phantom with thermoluminescence dosimeter. J Biomed Phys Eng, 9(2): 179-88. DOI: 10.31661/jbpe.v0i0.1067 [DOI:10.31661/jbpe.v0i0.1067]
7. Senkus-Konefka E, Jassem J (2006) Complications of breast-cancer radiotherapy. Clin Oncol, 18(3): 229-35. DOI:10.1016/j.clon.2005.11.004 [DOI:10.1016/j.clon.2005.11.004]
8. Reboucas LM, Campos CS, D'Amico GM, et al. (2019) Once‐weekly hypofractionated radiotherapy for breast cancer: First results of a phase II clinical trial. Breast J, 25(5): 953-7. DOI:10.1111/tbj.13372 [DOI:10.1111/tbj.13372]
9. Rastogi K, Jain S, Bhatnagar AR, et al. (2018) A comparative study of hypofractionated and conventional radiotherapy in postmastectomy breast cancer patients. Asia-Pac J Oncol Nurs, 5(1): 107-13. DOI:10.4103/apjon.apjon_46_17 [DOI:10.4103/apjon.apjon_46_17]
10. Wang S-L, Fang H, Song Y-W, et al. (2019) Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol, 20(3): 352-60. DOI:10.1016/S1470-2045(18)30813-1 [DOI:10.1016/S1470-2045(18)30813-1]
11. Kumbhaj P, Sharma R, Saini P, et al. (2013) A study of two different dose fractionation schedules of post mastectomy chest wall irradiation in carcinoma breast patients. Int J Med Sci Public Health, 2(4): 1001-5. DOI:10.5455/ijmsph.2013.040820131 [DOI:10.5455/ijmsph.2013.040820131]
12. Versmessen H, Vinh-Hung V, Van Parijs H, et al. (2012) Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy. BMC cancer, 12: 1-16. DOI:10.1186/1471-2407-12-495 [DOI:10.1186/1471-2407-12-495]
13. Parekh A, Dholakia AD, Zabranksy DJ, et al. (2018) Predictors of radiation-induced acute skin toxicity in breast cancer at a single institution: Role of fractionation and treatment volume. Adv Radiat Oncol, 3(1): 8-15. DOI:10.1016/j.adro.2017.10.007 [DOI:10.1016/j.adro.2017.10.007]
14. Arsenault J, Parpia S, Goldberg M, et al. (2020) Acute toxicity and quality of life of hypofractionated radiation therapy for breast cancer. Int J Radiat Oncol Biol Phys, 107(5): 943-8. DOI:10.1016/j.ijrobp.2020.03.049 [DOI:10.1016/j.ijrobp.2020.03.049]
15. Saber K, Madadizadeh F, Abdollahi-Dehkordi S, et al. (2024) Psychometric properties of the COVID-19 safety measures questionnaire in the employees of the radiation therapy center. J Educ Health Promot, 13(1): 95-101. DOI:10.4103/jehp.jehp_1007_22 [DOI:10.4103/jehp.jehp_1007_22]
16. Venigalla S, Guttmann DM, Jain V, et al. (2018) Trends and patterns of utilization of hypofractionated postmastectomy radiotherapy: a National Cancer Database analysis. Clin Breast Cancer, 18(5): e899-e908. DOI:10.1016/j.clbc.2018.02.009 [DOI:10.1016/j.clbc.2018.02.009]
17. Jd C (1995) Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys, 31: 1341-6. DOI:10.1016/0360-3016(95)00060-C [DOI:10.1016/0360-3016(95)00060-C]
18. Chu C-N, Hu K-C, Wu RS-C, et al. (2021) Radiation-irritated skin and hyperpigmentation may impact the quality of life of breast cancer patients after whole breast radiotherapy. BMC cancer, 21: 1-8. DOI:10.1186/s12885-021-08047-5 [DOI:10.1186/s12885-021-08047-5]
19. Soonthornrak J, Amornwichet N, Shotelersuk K, et al. (2022) Toxicity and cosmetic outcome in hypofractionated radiation therapy for ductal carcinoma in situ after breast-conserving surgery: a preliminary report. Int J Radiat Res, 20(2): 383-7. DOI:10.52547/ijrr.20.2.19 [DOI:10.52547/ijrr.20.2.19]
20. Linares I, Tovar MI, Zurita M, et al. (2016) Hypofractionated breast radiation: Shorter scheme, lower toxicity. Clin Breast Cancer, 16(4): 262-8. DOI:10.1016/j.clbc.2015.09.012 [DOI:10.1016/j.clbc.2015.09.012]
21. Zhao S, Liu Y, Huang F, et al. (2017) The long-term outcome of adjuvant hypofractionated radiotherapy and conventional fractionated radiotherapy after breast-conserving surgery for early breast cancer: a prospective analysis of 107 cases. J Thorac Dis, 9(10): 3840-50. DOI:10.21037/jtd.2017.09.125 [DOI:10.21037/jtd.2017.09.125]
22. Liu L, Yang Y, Guo Q, et al. (2020) Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review. Radiat Oncol, 15: 1-15. DOI: 10.1186/s13014-020-1463-1 [DOI:10.1186/s13014-020-1463-1]
23. Hashemi FA, Barzegartahamtan M, Mohammadpour RA, et al. (2016) Comparison of conventional and hypofractionated radiotherapy in breast cancer patients in terms of 5-year survival, locoregional recurrence, late skin complications and cosmetic results. Asian Pacific journal of cancer prevention: APJCP, 17(11): 4819-23. DOI:10.22034/APJCP.2016.17.11.4819
24. Gu L, Dai W, Fu R, et al. (2021) Comparing hypofractionated with conventional fractionated radiotherapy after breast-conserving surgery for early breast cancer: a meta-analysis of randomized controlled trials. Front Oncol, 11: 753209. DOI:10.3389/fonc.2021.753209 [DOI:10.3389/fonc.2021.753209]
25. Schmeel LC, Koch D, Schmeel FC, et al. (2020) Acute radiation-induced skin toxicity in hypofractionated vs. conventional whole-breast irradiation: An objective, randomized multicenter assessment using spectrophotometry. Radiother Oncol, 146: 172-9. DOI:10.1016/j.radonc.2020.02.018 [DOI:10.1016/j.radonc.2020.02.018]
26. Maiti S, Meyur S, Mandal BC, et al. (2021) Comparison of conventional and hypofractionated radiation after mastectomy in locally advanced breast cancer: a prospective randomised study on dosimetric evaluation and treatment outcome. J Radiother Pract, 20(1): 30-8. DOI:10.1017/S1460396919000992. [DOI:10.1017/S1460396919000992]
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