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Survival advantage of radiotherapy in triple-negative inflammatory breast cancer: A national cohort study
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Z.H. Zhang   , Y.Y. Li , Z.Y. He |
| Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, P. R. China , hezhy2253@163.com |
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Abstract: (14 Views) |
Background: Inflammatory breast cancer (IBC) is an aggressive subtype of breast carcinoma for which radiotherapy (RT) is a recommended treatment. This retrospective analysis aimed to clarify the impact of RT on survival outcomes among patients with IBC, stratified by molecular subtype. Materials and Methods: Data concerning IBC patients diagnosed from 2010 through 2015 was based on the SEER (Surveillance, Epidemiology, and End Results) database. To evaluate survival differences among women with diverse molecular subtypes, comparisons were drawn between those treated with RT and those untreated, employing Cox proportional hazards modeling, Kaplan-Meier (KM) curves, and chi-square analysis. Results: The cohort included 532 female patients, of whom 263 (49.4%) received radiotherapy. Nodal involvement, metastatic status, and chemotherapy use were each significantly correlated with the likelihood of receiving RT (all P < 0.05). Longer survival was exhibited in overall molecular subtypes who received RT(P<0.001). RT significantly improved outcomes in IBC cases of the hormone receptor (HR)-/human epidermal growth factor (HER2)- phenotype (OR, odds ratio = 0.525 [0.334–0.823], P = 0.005), whereas those with HR+/HER2-, HR+/HER2+ or HR-/HER2+ subtypes had a comparable prognosis between the RT cohort and non-RT cohort. HR-/HER2- patients with pathologic stage N0-2M0 had longer survival with RT (OR=0.354 [0.178-0.704], P=0.003), whereas those with N3M0 stage (P=0.880) or M1 stage (P=0.443) derived no benefit. Conclusion: Marked improvements in survival following RT were noted for HR−/HER2− IBC with pathologic N0–2M0 staging. |
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| Keywords: Inflammatory breast neoplasms, radiotherapy, survival analysis, retrospective studies, SEER program. |
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Full-Text [PDF 1108 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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