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Evaluation of the critical organ doses in high dose rate brachytherapy plans using single-and multi-channel applicators
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L. Suncak   , C.K. Akbas , G.U. Alveroglu , S. Özkurt , K.A. İbiş , S. Küçücük , H.B. Becerir |
| The Institute of Health Sciences at Istanbul University, Istanbul, Turkey , lxleyla@hotmail.com |
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Abstract: (14 Views) |
Background: The purpose of our study was to investigate the doses received by critical organs, namely the bladder, rectum, and sigmoid colon, in the treatment plans using single-channel (SC) or multi-channel (MC) applicators in high dose rate (HDR) brachytherapy treatments for vaginal cancer patients. Materials and Methods: We established treatment plans for 10 patients received 45Gy (1.8Gy×25fractions) external radiotherapy and then subsequently treated with HDR brachytherapy using MC applicators in the Oncentra Brachytherapy Treatment Planning System (OBTPS). These plans, originally created with MC applicator in the OBTPS, were redefined to simulate an SC applicator, where only the central channel active was kept active. To compare the doses to critical organs, new plans were generated with a prescribed dose of 5Gy to the clinical target volume (CTV). During optimization, it was ensured that 90% of the CTV received the prescribed dose (5Gy), in accordance with Groupe Européen de Curiethérapie and the European SocieTy for Radiotherapy and Oncology (GEC-ESTRO) criteria. The doses received by critical organs were analyzed for volumes of 0.1, 1, and 2cc in both SC and MC applicator plans. Results: A significant difference was found in rectal doses at 1cc and 2cc (p=0.022 and p=0.022, respectively); bladder doses at 0.1cc 1cc and 2cc (p=0.013 for all); and sigmoid colon dose at 1cc (p=0.012). Conclusion: HDR brachytherapy plans using MC applicators delivered lower doses to critical organs compared to SC applicators. Thus, MC applicators are preferable for better organ sparing in vaginal cancer treatment. |
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| Keywords: Brachytherapy, rectum, sigmoid colon, urinary bladder, applicators. |
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Full-Text [PDF 922 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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