|
Diagnostic value of multi-slice spiral computed tomography combined with carcinoembryonic antigen and Wnt pathway inhibitor for early-stage lung cancer
|
X. Zhang   , X. Wu , G. Wang |
| Department of Respiratory and Critical Care Medicine, The official name of our hospital has been changed into 301 Hospital, Beijing, China |
|
|
Abstract: (38 Views) |
Background: We aimed to analyze the significance of multi-slice spiral computed tomography (CT) combined with carcinoembryonic antigen (CEA) and Wnt pathway inhibitor (DKK1) for the diagnosis of early-stage lung carcinoma. Materials and Methods: Subjects (102 in total) were selected from patients with suspected early-stage lung carcinoma receiving treatment in the hospital. Multi-slice spiral CT was performed on all subjects, CEA and DKK1 levels in the serum were detected, and the diagnostic efficiency of multi-slice spiral CT for early-stage lung cancer was analyzed. Results: The sensitivity of 94.25% (82/87), Youden index of 0.743, specificity of 80.00% (12/15), accuracy of 92.16% (94/102), positive diagnostic value of 96.47% (82/85), and negative diagnostic value of 70.59% (12/17) were obtained for multi-slice spiral CT in diagnosing early-stage lung cancer. As revealed by receiver operating characteristic curve analysis results, multi-slice spiral CT parameters combined with CEA and DKK1 had an area under the curve of 0.954, sensitivity of 95.22% and specificity of 86.17% in the diagnosis of early-stage lung carcinoma, significantly superior to multi-slice spiral CT parameters, CEA or DKK1 alone (P<0.05). Conclusion: The combination of CEA and DKK1 with multi-slice spiral CT can improve the diagnostic efficiency for early-stage lung cancer. |
|
| Keywords: Carcinoembryonic antigen, diagnosis, lung neoplasms, CT. |
|
|
Full-Text [PDF 820 kb]
(4 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
