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Diagnostic value of circRNA-UBAP2 and CXCR4 mRNA expression combined with endoscopic ultrasonography in colorectal cancer
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J. Duan   , Z. Gao , Z. Yang , W. Huang , X. Guan , Y. Wang |
| Gastroenterology, Beihua University Affiliated Hospital, Jilin, Jilin Province, China , 15043210800@163.com |
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Abstract: (39 Views) |
Background: To investigate the clinical value of combining the expression of circular RNA ubiquitin associated protein 2 (circRNA-UBAP2) and chemokine receptor 4 (CXCR4) messenger RNA（mRNA） with endoscopic ultrasonography for the diagnosis of colorectal cancer (CRC). Materials and Methods: A retrospective study was conducted. 104 patients with CRC and 87 patients with colorectal adenoma who were admitted to the hospital from May 2022 to May 2024 were enrolled in the study. The expression levels of circRNA-UBAP2 and CXCR4 mRNA in samples were detected. The relationship between the expression of circRNA-UBAP2 and CXCR4 mRNA and clinicopathological features of patients with CRC was analyzed, and the diagnostic efficacy of circRNA-UBAP2 and CXCR4 mRNA combined with endoscopic ultrasonography for CRC were evaluated. Results: The expression levels of circRNA-UBAP2 and CXCR4 mRNA in cancer tissues of patients with CRC were higher than those in adjacent tissues (P<0.05). Statistically significant differences in the expression levels of circRNA-UBAP2 and CXCR4 mRNA were observed among patients with different differentiation degrees, TNM stages, and lymph node metastasis status (P<0.05). The accuracy of endoscopic ultrasonography in diagnosing CRC was 87.96% (kappa value=0.758). The AUC (95% CI) of joint diagnosis was 0.980 (0.958-1.000), which was larger than that of separate diagnosis (P<0.05). Conclusion: circRNA-UBAP2 and CXCR4 mRNA are highly expressed in patients with CRC, and are associated with differentiation degree, TNM staging, and lymph node metastasis. The two are helpful in distinguishing CRC from colorectal adenoma, and their combination with endoscopic ultrasonography can improve diagnostic efficacy. |
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| Keywords: Colorectal cancer, endoscopic ultrasonography, ubiquitin associated protein 2, chemokine receptor 4. |
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Full-Text [PDF 1080 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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