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Association of C3AR1 gene polymorphism with sepsis susceptibility and prognosis in colorectal cancer patients undergoing radiotherapy
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H. Zhao   , M. Jiang , Z. Li , L. Mao , J. Miao , W. Wang , Y. Sun |
| Department of Geriatrics, Zhejiang Xin'an International Hospital, Jiaxing City, Zhejiang Province, China , 365845111@qq.com |
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Abstract: (49 Views) |
Background: This study explores the association between C3AR1 gene polymorphisms and sepsis susceptibility and prognosis in colorectal cancer patients undergoing radiotherapy, aiming to enhance genetic insights and clinical management. Materials and Methods: We enrolled 100 colorectal cancer patients with sepsis during radiotherapy and 80 healthy controls. DNA was extracted from blood samples, and serum CEA and VEGF levels were measured pre- and post-radiotherapy. Four C3AR1 polymorphisms (rs11567806, rs190043630, rs113825556, rs147364229) were genotyped. Hardy-Weinberg equilibrium, χ² tests, and logistic regression were used for analysis. Radiotherapy included 2 Gy daily fractions for 5 weeks. Results: The sepsis and non-sepsis groups were similar in age, gender, BMI, WBC count, infection site, and smoking history (P>0.05). The sepsis group had higher APACHE II scores (14.65±4.23 vs. 12.90±3.87, P=0.006) and PCT levels (45.87±9.76 g/L vs. 8.92±2.73 g/L, P<0.01). C3AR1 polymorphisms showed no significant association with sepsis susceptibility. However, the CC genotype of rs190043630 was linked to poorer prognosis (P=0.044). Post-radiotherapy, CEA (22.3±7.5 to 12.4±6.1 ng/mL, P<0.001) and VEGF (123.4±42.5 to 54.2±28.1 pg/mL, P<0.01) levels decreased significantly in the ACD + radiotherapy group. Conclusion: C3AR1 polymorphisms rs11567806 and rs190043630 are not linked to sepsis susceptibility, but the rs190043630 CC genotype predicts poorer prognosis. Radiotherapy enhances biomarker reduction, suggesting a synergistic effect with chemotherapy. |
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| Keywords: C3AR1, polymorphism, sepsis, colorectal cancer, radiotherapy, prognosis, CEA, VEGF. |
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Full-Text [PDF 868 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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