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Histomorphology of liver tissue and electrical impedance changes due to rats exposed to Ionizing radiation above a specific dose
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S.K. Sung   , G.R. Kim , M.S. Lee , G.D. Kim , C.H. Lee , H.J. Cho , J. H. Kwak , S. H. Kil |
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Abstract: (8 Views) |
Background: This study investigated the relationship between histomorphological changes and electrical resistance in liver tissue following radiation exposure in a rat model. Materials and Methods: Five-week-old Sprague–Dawley rats were exposed to ionizing radiation at doses of 1, 5, 10, and 20 Gy. Impedance changes were measured using alternating current (AC) frequencies ranging from 1 kHz to 1 MHz. Gross physical signs were monitored four days post-irradiation. Transmission electron microscopy (TEM) was employed to assess histological alterations in liver tissue. Results: As the radiation dose increased, notable gross changes in general signs were observed. Impedance characteristics varied according to dose, reflecting underlying histological alterations. Ultrastructural examination revealed damage to intracellular organelles, likely resulting from disrupted mitotic activity in irradiated liver tissue. Conclusion: Radiation exposure induces dose-dependent histomorphological changes and corresponding alterations in electrical impedance in rat liver tissue. These findings provide insights into the relationship between tissue structure and bioelectrical properties under radiation stress. |
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| Keywords: Electric impedance, radiation effects, liver, microscopy electron transmission. |
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Full-Text [PDF 961 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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