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Clinical features and prognostic analysis of early-onset gastric cancer treated with radiotherapy
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X. Kang   , X. Meng , G. Guo , Y. Nian |
| Department of Gastroenterology, Second Affiliated Hospital of Baotou Medical College, Baotou, 014000, China , nianyuanyuannina@163.com |
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Abstract: (10 Views) |
Background: This study examines the clinicopathological characteristics, recurrence patterns, and survival outcomes of early-onset gastric cancer (EOGC) patients treated with radiotherapy, comparing them with non-early-onset gastric cancer (NEOGC) patients to evaluate prognostic differences and the effectiveness of radiotherapy-based treatments. Materials and Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database (2010-2015), analyzing 814 EOGC and 4,997 NEOGC patients who underwent radiotherapy. Descriptive statistics characterized clinical and pathological features. Kaplan-Meier survival analysis and log-rank tests compared overall survival (OS). Cox proportional hazards regression models identified independent prognostic factors. Results: EOGC patients showed a higher proportion of females (42.3%) and advanced-stage disease (44.3%) compared to NEOGC. Signet-ring cell carcinoma was more prevalent in EOGC (26.8% vs. 14.7%, P < 0.001). Tumors in EOGC were predominantly located in the gastric body, fundus, and greater curvature (P < 0.001). Adjuvant radiotherapy was more common in EOGC (78.9% vs. 68.3%, P < 0.001). Survival analysis indicated that radiotherapy alone provided superior OS compared to combined chemoradiotherapy or surgery-radiotherapy approaches. Cox regression identified tumor stage, histological subtype, and radiotherapy modality as key prognostic factors. Conclusion: EOGC treated with radiotherapy exhibits distinct clinicopathological features, including more aggressive histological subtypes. Radiotherapy as monotherapy offers better long-term survival than multimodal treatments. These findings underscore the need for personalized radiotherapy strategies to optimize prognosis in EOGC. |
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| Keywords: Early-onset gastric cancer, stomach neoplasms, radiotherapy, prognosis, survival analysis. |
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Full-Text [PDF 986 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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