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FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment
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T.A. Heusner   , C. Mikat , S. Hahn , J. Altenbernd , A. Stahl , A. Bockisch , M. Forsting , G. Antoch |
| , Heusner@med.uni-duesseldorf.de |
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Abstract: (11702 Views) |
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Background: To retrospectively describe imaging
characteristics of liver metastases on fused FDG-PET/
MRI data sets and to compare the diagnostic
accuracy of MRI and fused FDG-PET/MRI data sets
for the detection of liver metastases in patients
undergoing systemic anticancer treatment. Materials
and Methods: 43 oncological patients (mean age:
56+/- 11 years) were investigated by FDG-PET/CT
and liver MRI. FDG-PET data from PET/CT scans were
fused with MRI. 556 lesions were evaluated. 5 different
evaluation algorithms were used for FDG-PET/
MRI evaluation. The sensitivity, specifity, PPV, NPV
and accuracy of MRI and FDG-PET/MRI data for the
detection of liver metastases were calculated. A
mean follow-up of 647 days served as reference
standard. McNemar’s test was used to test for
statistically significant differences between MRI and
FDG-PET/MRI (p<0.5). Results: The sensitivity, specificity,
PPV, NPV and accuracy of MRI for the detection
of liver metastases were 86%, 81%, 97%, 47%, and
85% and 50%, 100%, 100%, 22%, and 56%, for FDGPET/
MRI. FDG-PET/MRI was significantly less
accurate than MRI alone (p<.001). Conclusion: In
opposite to patients before systemic anticancer
therapy the fusion of FDG-PET data with liver MRI
cannot be recommended for the detection of liver
metastases in patients undergoing systemic oncological
therapy. Iran. J. Radiat. Res., 2012 9(4): 209-219
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| Keywords: PET/MRI, PET/CT, liver MRI, liver metastases, hybrid imaging |
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Full-Text [PDF 400 kb]
(2624 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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