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Effects of repeated ultraviolet-C radiation on tissues: A Guinea pig model study
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| O. Ozmen, V. Ipek, S.A. Tasan, L.E.O. Ayozger, M. Altintas |
| Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey , ozlemozmen@mehmetakif.edu.tr |
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Abstract: (203 Views) |
Background: Due to the disinfection and antibiotic resistance of microorganisms, there is a growing interest in ultraviolet-C (UV-C). UV-C has numerous advantages, and the applications of this method for fluids, surfaces, and air are rapidly expanding. However, nothing is known about how UV-C affects living bodies. This study's objective is to assess the results of 10 sessions of 10- to 20-minute UV-C exposure on healthy guinea pigs. Materials and Methods: After five days of UV-C treatment, blood and visceral organ samples were collected and analyzed. Results: Moreover, the hematological and biochemical analyses of the blood samples revealed no significant changes. According to histopathological examination, UV-C treatment did not cause any damage to internal organs. Except for the intestine, caspase-3 immunohistochemistry revealed no increase in apoptotic activity. In the UV-C-treated groups, only minor apoptotic activity was observed in intestinal goblet cells. Conclusion: This study found that repeated UV-C exposure for ten sessions lasting 10-20 minutes did not result in any pathological findings in the guinea pig model. This result suggested that UV-C could be used for barn and pen disinfection when animals are present as well as udder disinfection prior to milking. |
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| Keywords: UV-C, treatment, Guinea pig, pathology. |
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Full-Text [PDF 1272 kb]
(229 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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