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Application of preoperative DCE-MRI quantitative parameters combined with serum VEGFR-3 in the evaluation of mediastinal lymph node metastasis of adenocarcinoma of lung
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J. Yang   , P. Guo , D. Zhou , L. Ding , P. Jiang |
| Department of Radiology, Huanggang Central Hospital, Huanggang, Hubei, China , hgszxyycgzs201106@163.com |
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Abstract: (48 Views) |
Background: To observe the expression of serum vascular endothelial growth factor receptor-3 (VEGFR-3) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in patients with lung adenocarcinoma (AOL) mediastinal lymph node metastasis (MLNM), and analyze the relationship between the above parameter and MLNM of AOL. Materials and Methods: One hundred patients with AOL, they were divided into MLNM group and non-MLNM group. Two groups were compared in the DCE-MRI quantitative parameters [Rate constant (Kep), volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve), and apparent diffusion coefficient (ADC)] and serum VEGFR-3 expression, and the relationship between the above index parameters and MLNM in patients with AOL was analyzed. Results: Compared with the non-MLNM group, the Ktrans, Kep, Ve value and expression of serum VEGFR-3 in the MLNM group were higher, the ADC value was lower (P<0.05). Logistics regression analysis showed that preoperative fasting serum VEGFR-3 expression was related to MLNM in patients with AOL, and high VEGFR-3 expression might be a risk factor for MLNM in patients with AOL (OR>1, P<0.05). The ROC curve showed that the AUC of VEGFR-3 and DCE-MRI quantitative parameters to predict MLNM in patients with AOL was greater than 0.70. Conclusion: The DCE-MRI quantitative parameters combined with serum VEGFR-3 expression has a certain value in the preoperative assessment of MLNM in patients with AOL. |
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| Keywords: Adenocarcinoma of lung, magnetic resonance imaging, vascular endothelial growth factor receptor-3, lymphatic metastasis, diagnosis. |
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Full-Text [PDF 1041 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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