[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Number 4 (3-2012) ::
IJRR 2012, 9(4): 209-219 Back to browse issues page
FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment
Dr. T.A. Heusner , C. Mikat, S. Hahn, J. Altenbernd, A. Stahl, A. Bockisch, M. Forsting, G. Antoch
, Heusner@med.uni-duesseldorf.de
Abstract:   (6433 Views)
Background: To retrospectively describe imaging characteristics of liver metastases on fused FDG-PET/ MRI data sets and to compare the diagnostic accuracy of MRI and fused FDG-PET/MRI data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. Materials and Methods: 43 oncological patients (mean age: 56+/- 11 years) were investigated by FDG-PET/CT and liver MRI. FDG-PET data from PET/CT scans were fused with MRI. 556 lesions were evaluated. 5 different evaluation algorithms were used for FDG-PET/ MRI evaluation. The sensitivity, specifity, PPV, NPV and accuracy of MRI and FDG-PET/MRI data for the detection of liver metastases were calculated. A mean follow-up of 647 days served as reference standard. McNemar’s test was used to test for statistically significant differences between MRI and FDG-PET/MRI (p<0.5). Results: The sensitivity, specificity, PPV, NPV and accuracy of MRI for the detection of liver metastases were 86%, 81%, 97%, 47%, and 85% and 50%, 100%, 100%, 22%, and 56%, for FDGPET/ MRI. FDG-PET/MRI was significantly less accurate than MRI alone (p<.001). Conclusion: In opposite to patients before systemic anticancer therapy the fusion of FDG-PET data with liver MRI cannot be recommended for the detection of liver metastases in patients undergoing systemic oncological therapy. Iran. J. Radiat. Res., 2012 9(4): 209-219
Keywords: PET/MRI, PET/CT, liver MRI, liver metastases, hybrid imaging
Full-Text [PDF 400 kb]   (1510 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heusner T, Mikat C, Hahn S, Altenbernd J, Stahl A, Bockisch A, et al . FDG-PET/MRI fused data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. IJRR. 2012; 9 (4) :209-219
URL: http://ijrr.com/article-1-814-en.html
Volume 9, Number 4 (3-2012) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.053 seconds with 808 queries by yektaweb 3479