[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 2 (4-2014) ::
Int J Radiat Res 2014, 12(2): 129-138 Back to browse issues page
Quantitative SPECT and planar 32P bremsstrahlung imaging for dosimetry purpose –An experimental phantom study
M.R. Teimoori Sichani, M. Amoui, Sh. Akhlaghpoor, M. Hosntalab
Noor Medical Imaging Center, Tehran, Iran , akhlaghpoor@pardisnoor.com
Abstract:   (8732 Views)

Background: In this study, Quantitative 32P bremsstrahlung planar and SPECT imaging and consequent dose assessment were carried out as a comprehensive phantom study to define an appropriate method for accurate Dosimetry in clinical practice. Materials and Methods: CT, planar and SPECT bremsstrahlung images of Jaszczak phantom containing a known activity of 32P were acquired. In addition, Phantom contour was determined for attenuation correction and image registration. Reconstructed SPECT slices were corrected for attenuation effect using two different methods: conventional Chang`s method and an expectation maximization algorithm followed by CT and SPECT image registration. Cumulated activity was calculated by a predefined calibration factor. Both attenuation correction algorithms were quantitatively assessed by the Monte Carlo SIMIND program. Acquired planar Bremsstrahlung images were quantified by the Conjugate View Method, as well. Results: Calculated activities were statistically different among various quantification methods (P= 0.0001). When iterative expectation maximization algorithm and applied methods were used, mean calculated activity had the least difference with real activity of ±3%. Conclusion: Quantitative 32P Bremsstrahlung SPECT imaging could accurately determine administered activity and assess radiation dose if precise attenuation correction and appropriate registration with CT were done even without sophisticated scatter correction or when SPECT/CT machines are not available. Therefore, it has the potential of specific tumor/organ dosimetry in clinical practice. The best method for calculating activity is quantitative SPECT using iterative expectation maximization algorithm. Additionally, applied method for determining phantom contour was practical for attenuation correction and image registration.

Keywords: Bremsstrahlung imaging, quantitative SPECT imaging, attenuation correction, Phosphorus-32, activity determination, dosimetry
Full-Text [PDF 912 kb]   (2085 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Teimoori Sichani M, Amoui M, Akhlaghpoor S, Hosntalab M. Quantitative SPECT and planar 32P bremsstrahlung imaging for dosimetry purpose –An experimental phantom study. Int J Radiat Res. 2014; 12 (2) :129-138
URL: http://ijrr.com/article-1-1223-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 2 (4-2014) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4419