Background: The aims of the study are to determine the radioactivity concentrations of ²²⁶Ra, ²³⁸U, ²³²Th and ⁴⁰K in vegetables of a recently found high background radiation area of south-eastern part of Bangladesh and to detect the radiological risks to human from intake of these vegetables. Materials and Method: 10 plant samples were collected randomly from different locations of the study area. The radio-nuclides in papaya were measured by direct &gamma-ray spectrometry using HPGe detector. Results: The average activity concentrations of ²²⁶Ra, ²³⁸U, 232Th and ⁴⁰K in papaya samples were 80.95±13.61, 64.77±38.47, 83.53±20.50 and 1691.45±244.98 Bq kg^-1 respectively. The annual effective ingestion dose due to intake of papaya was 1.1 mSv Y^-1. Conclusion: The concentrations of radio-nuclides in the papaya samples found in present study were higher than the world average values suggested by the UNSCEAR. The annual effective ingestion dose was found 3.8 times higher than total exposure per person resulting from the ingestion of terrestrial radioisotopes.