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:: Volume 12, Issue 4 (10-2014) ::
Int J Radiat Res 2014, 12(4): 303-309 Back to browse issues page
Optimization of clinical target volume delineation using magnetic resonance spectroscopic imaging (MRSI) in 3D conformal radiotherapy of prostate cancer
M. Robatjazi, S.R. Mahdavi, A.R. Nikofar, B. Bolouri, H.R. Baghani
Department of Medical Physics, Iran University of Medical sciences, Tehran, Iran , srmahdavi@hotmail.com
Abstract:   (7219 Views)

Background: For the purpose of individual clinical target volume assessment in radiotherapy of prostate cancer, MRSI was used as a molecular imaging modality with MRI and CT images. Materials and Methods: The images of 20 prostate cancer patients were used in this study. The MR and MRSI images were registered with CT ones using non-rigid registration technique. The CT based planning (BP), CT/MRI BP and CT/MRSI BP was performed for each patient. For plan evaluation, Dose Volume Histograms (DVHs) data were used. A paired sample T-test was used for the analysis of the obtained data. Results: The percentage of variation of CTVMRI to CTVCT and PTVMRI to PTVCT were 12.83% and 8.97%, respectively. CTVMRSI and PTVMRSI were 21% and 27.41% more than their corresponding values of CT volumes. The mean percentage of variation in rectum volume that received 60% of the prescribe dose (V60R) in MRSI/CT BP relative to CT BP was 14.66%. Conclusion: The use of MRSI in detecting of prostate adenocarcinoma could provide some decisive information to determine optimum volume and safe margin for target definition to improve adaptive radiotherapy in prostate cancer.

Keywords: MRSI, MRI, prostate cancer, 3D-CRT radiotherapy, target definition
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Type of Study: Original Research | Subject: Radiation Biology
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Robatjazi M, Mahdavi S, Nikofar A, Bolouri B, Baghani H. Optimization of clinical target volume delineation using magnetic resonance spectroscopic imaging (MRSI) in 3D conformal radiotherapy of prostate cancer. Int J Radiat Res. 2014; 12 (4) :303-309
URL: http://ijrr.com/article-1-1347-en.html


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Volume 12, Issue 4 (10-2014) Back to browse issues page
International Journal of Radiation Research
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