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:: Volume 14, Issue 2 (4-2016) ::
Int J Radiat Res 2016, 14(2): 119-125 Back to browse issues page
Evaluating the effect of Zinc Oxide nanoparticles doped with Gadolinium on dose enhancement factor by PRESAGE dosimeter
N. Banaee, H.A. Nedaie, A.R. Shirazi, A.R. Zirak, S. Sadjadi
Tehran University of Medical Sciences , Nedaieha@sina.tums.ac.ir
Abstract:   (7225 Views)

Background: New treatment modalities are developed with the aim of escalating tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibilities including destroying cancer tumors with minimal damage to healthy tissues. Zinc Oxide nanoparticles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on increasing the absorbed dose of target volume especially when doped with a high Z element. The aim of this study was to evaluate the effect of ZnO NPs doped with Gadolinium (Gd) on dose enhancement factor by 6MV photon beam irradiation. Materials and Methods: Various concentrations of ZnO NPs doped with 5% Gd were incorporated into PRESAGE composition, the 3D chemical dosimeter. Then by using a UV-Vis spectrophotometer optical density changes and also dose enhancement factor (DEF) were determined. Results: The results of this study showed that by incorporating 500, 1000, 3000 and 4000 µg/ml ZnO NPs doped with Gd into PRESAGE structure the dose enhancement factor of about 1.57, 1.69, 1.78 and 1.82 in a 15 ×15 cm2 field size could be found, respectively. Conclusion: The results of this study showed that ZnO NPs doped with Gd could be considered as new compound for increasing the absorbed dose.

Keywords: Zinc Oxide, Gadolinium, Nanoparticle, PRESAGE, DEF
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Type of Study: Original Research | Subject: Radiation Biology
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Banaee N, Nedaie H, Shirazi A, Zirak A, Sadjadi S. Evaluating the effect of Zinc Oxide nanoparticles doped with Gadolinium on dose enhancement factor by PRESAGE dosimeter. Int J Radiat Res. 2016; 14 (2) :119-125
URL: http://ijrr.com/article-1-1715-en.html


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Volume 14, Issue 2 (4-2016) Back to browse issues page
International Journal of Radiation Research
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