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:: Volume 16, Issue 3 (7-2018) ::
Int J Radiat Res 2018, 16(3): 257-267 Back to browse issues page
Treatment outcomes of (chemo) radiotherapy for oropharyngeal cancers: influence of the use of 15 MV X-rays in radiation boost
H. Kaizu , M. Hata, S. Takano, T. Kasuya, G. Nishimura, I. Koike, T. Taguchi, N. Oridate
Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan , hkaizu1980@ybb.ne.jp
Abstract:   (4464 Views)
Background: Using high energy X-rays (>10 MV) as a radiotherapy boost in treating oropharyngeal cancers (OPC) to reduce mandible radiation exposure may result in deterioration of disease control rates due to re-build-up of X-rays at the tumor surface. Therefore, we retrospectively compared the treatment outcomes and toxicities in OPC patients treated with radiotherapy using 15 MV and/or 4–6 MV X-rays as a boost. Materials and Methods: Between 2008 and 2014, 63 OPC patients received definitive 3-dimensional conformal radiotherapy. The median total dose was 70.2 (range, 46.8–75.6) Gy. The median follow-up period for surviving patients was 48 (range, 9–88) months. Twenty-one patients (33.3%) received a boost employing 15 MV X-ray in at least one beam during treatment, and 42 patients (66.7%) received only 4–6 MV X-rays. Local control (LC), locoregional control (LRC), disease-free survival (DFS), overall survival (OS) rates and the incidence of osteoradionecrosis (ORN) in the mandible for the two cohorts were estimated using the Kaplan-Meier method and compared using the log-rank test. Results: There were no statistically significant differences between the two cohorts in either treatment outcomes (3-year LC, 81% versus 75% [p=0.742]; 3-year LRC, 71% versus 71% [p=0.925]; 3-year DFS, 66% versus 66% [p=0.934]; 3-year OS, 65% versus 78% [p=0.321]) or incidence of grade >2 ORN in the mandible (9.5% versus 11.9% [p=0.883]). Conclusion: Employing 15 MV X-rays in a boost may provide comparable treatment outcomes to 4–6 MV X-rays. However, reduction in the incidence of ORN in the mandible was not demonstrated.
Keywords: Oropharyngeal cancer, osteoradionecrosis, radiotherapy.
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Type of Study: Original Research | Subject: Radiation Biology
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Kaizu H, Hata M, Takano S, Kasuya T, Nishimura G, Koike I, et al . Treatment outcomes of (chemo) radiotherapy for oropharyngeal cancers: influence of the use of 15 MV X-rays in radiation boost . Int J Radiat Res. 2018; 16 (3) :257-267
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Volume 16, Issue 3 (7-2018) Back to browse issues page
International Journal of Radiation Research
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