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:: Volume 17, Issue 1 (1-2019) ::
Int J Radiat Res 2019, 17(1): 67-73 Back to browse issues page
Effects of N-acetylcysteine on life shortening induced by chronic low dose-rate gamma-ray exposure in mice
K. Yamauchi PhD , Y. Tsutsumi, K. Ichinohe, M. Yoneya, J.I. Komura, T. Ono, K. Tanaka
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan , yamauchi@ies.or.jp
Abstract:   (2044 Views)
Background: The development of methods to alleviate radiation-induced health effects is important for the practical use of radiation therapy and for understanding the molecular mechanisms mediating these effects. Here, we examined the protective capability of N-acetylcysteine (NAC) on life-shortening effects induced by continuous low dose-rate gamma-ray exposure in mice. Materials and Methods: Female B6C3F1 mice were exposed to gamma-rays for 400 days at a dose rate of 20 mGy/day beginning at 8 weeks of age. Control unexposed mice and exposed mice were divided into two groups; the first was provided with regular water, and the second was administered 40 mM NAC during the exposure period. Results: Although NAC administration did not affect the life span of non-irradiated mice (p = 0.232), a 59-days life extension was observed in the exposed group (p = 0.0177). Moreover, radiation exposure and NAC treatment affected body weight. The reduction of body weight observed in NAC treated mice was associated with a reduction in water intake. Conclusion: Our data demonstrated that the life-shortening effects of chronic low dose-rate radiation exposure in mice were alleviated by NAC administration.
Keywords: low dose-rate radiation, chronic exposure, life-shortening effect, N-acetylcysteine, mouse model.
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Type of Study: Original Research | Subject: Radiation Biology
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Yamauchi K, Tsutsumi Y, Ichinohe K, Yoneya M, Komura J, Ono T et al . Effects of N-acetylcysteine on life shortening induced by chronic low dose-rate gamma-ray exposure in mice. Int J Radiat Res. 2019; 17 (1) :67-73
URL: http://ijrr.com/article-1-2459-en.html

Volume 17, Issue 1 (1-2019) Back to browse issues page
International Journal of Radiation Research
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