[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 2 (4-2019) ::
Int J Radiat Res 2019, 17(2): 293-300 Back to browse issues page
Early toxicity of moderate hypofractionated volumetric modulated Arc radiotherapy for localized prostate cancer
H.J. Kim , J.S. Lee, W.C. Kim
Department of Radiation Oncology, Inha University Hospital, Inha University of Medicine, Inchon, Korea , cancerovercome@gmail.com
Abstract:   (1868 Views)
Background: Based on the radiation biology model of prostate cancer, hypofractionated radiotherapy can improve the treatment outcomes without increasing toxicity. Although hypofractionated radiotherapy is implemented over a short period of time, it is more convenient and cheaper compared with conventional fractionated treatment. The aim of this study was to investigate the early toxicity of moderate hypofractionated schedules with volumetric modulate arc radiotherapy (VMAT) for localized prostate. Materials and Methods: Between 2014-2017, 41 patients were treated using the volumetric modulated arc radiotherapy (VMAT) technique with image guided radiotherapy. The target volume for low risk patient (2.4%) was the prostate alone, and that for intermediate (43.9%) and high risk patients (53.7%) was prostate and two thirds of the seminal vesicles. A prescription dose of 70 Gy in 2.5 Gy daily for 28 treatment was used. Radiotherapy-related toxicity was scored according to the Common Terminology Criteria for Adverse Events 4.0 criteria. Results: Early genitourinary (GU) toxicity was recorded for grades 0, 1, 2 and 3 in 7 (17.1%), 25 (61.0%), 9 (21.9%) and 0 patients, respectively. Most common GU toxicities were urinary frequency and urgency. Early gastrointestinal (GI) toxicity was observed for grade 0, 1 and 2 in 35 (85.4%), 6 (14.6%) and 0 patients, respectively. Most common GI toxicity was rectal discomfort but interventional therapy was not indicated. Conclusion: The moderate hypofractionated VMAT radiation therapy with precise dose delivery technique appeared safe with low early toxicity. Longer follow up is needed to assess late toxicity and tumor control probability.
Keywords: Prostate cancer, acute toxicity, hypofractionation, volumetric modulated arc therapy, radiotherapy.
Full-Text [PDF 1631 kb]   (644 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kim H, Lee J, Kim W. Early toxicity of moderate hypofractionated volumetric modulated Arc radiotherapy for localized prostate cancer . Int J Radiat Res. 2019; 17 (2) :293-300
URL: http://ijrr.com/article-1-2526-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 2 (4-2019) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.04 seconds with 32 queries by YEKTAWEB 4355