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:: Volume 18, Issue 1 (1-2020) ::
Int J Radiat Res 2020, 18(1): 149-155 Back to browse issues page
Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model
C. Elsurer, Z.E. Celik, G. Yavas , C. Yavas
Selcuk University, Department of Radiation Oncology, Konya, Turkey , guler.aydinyavas@gmail.com
Abstract:   (1824 Views)
Background: Management of head and neck cancer includes surgical resection, chemotherapy and radiotherapy (RT). We hypothesized that pre-radiation treatment with a mineralocorticoid receptor (MR) antagonist, spironolactone (S), may have radioprotective effect on salivary glands. Materials and Methods: Study included 30 adult female Wistar albino rats. Rats were divided into four groups (G); G1, control group; G2, RT-only group, G3, S-only group; G4, RT plus S group. Rats were sacrificed at 6th hour; 21st and 100th days after RT. Salivary gland samples were taken for microscopical examination. Results: Periductal-perivascular inflammation scores in 21st and 100th days tended to be higher in G2 than in G4, but the difference was not statistically significant. Periductal-perivascular fibrosis score was significantly different between the groups in 100th day (P: 0.010). Pairwise comparisons revealed that periductal-perivascular fibrosis scores were different between G1 and G2 (P: 0.014), G2 and G3 (P: 0.014), G2 and G4 (P: 0.034). Conclusions: MR blockade with S, when initiated before RT, ameliorates late radiation-induced fibrosis in the submandibular glands.
Keywords: Inflammation, fibrosis, salivary gland, submandibular gland, radiotherapy, rat.
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Type of Study: Original Research | Subject: Radiation Biology
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Elsurer C, Celik Z, Yavas G, Yavas C. Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model. Int J Radiat Res. 2020; 18 (1) :149-155
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Volume 18, Issue 1 (1-2020) Back to browse issues page
International Journal of Radiation Research
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