[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 19, Issue 2 (4-2021) ::
Int J Radiat Res 2021, 19(2): 299-308 Back to browse issues page
Tc-99m (methylene diphosphonate) SPECT quantitative imaging: Impact of attenuation map generation from SPECT-non-attenuation corrected and MR images on the diagnosis of bone metastasis
S. Mostafapour , H. Arabi , F. Gholamiankhah , S.K. Razavi-Ratki , A.A. Parach
Department of Medical Physics, Faculty of medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , aliparach@ssu.ac.ir
Abstract:   (1549 Views)
Background: Single photon emission computed tomography (SPECT)-alone imaging using the Tc-99m radiopharmaceutical labeled with methylene diphosphonate or similar analogs is usually employed to diagnose metastatic bone and is typically followed by complementary magnetic resonance (MR) imaging for support in clinical decision-making. In this study, two attenuation map generation approaches from MR and SPECT non-attenuation corrected (SPECT-nonAC) images were evaluated in the context of quantitative SPECT imaging. Materials and Methods: The 2class-MR attenuation map was generated via segmenting an MR image into air and soft tissue. Likewise, SPECT-nonAC was segmented into background air and soft tissue to generate a 2class-SPECT attenuation map. The reference attenuation map was generated through manual bone segmentation from an MR image to develop a 3class-bone attenuation map. Standard uptake value (SUV) bias was calculated using the different attenuation maps on 50 vertebrae from normal patients and 16 vertebrae from metastatic patients. Results: The 2class-MR approach resulted in -16% and -8% SUV bias in normal and metastatic groups, respectively, while 2class-SPECT led to 33% and 26% SUV underestimation for the normal and metastatic patient groups, respectively. Conclusion: The 2class-SPECT approach led to a significant underestimation of SUV due to the uncertainty of body contour delineation. However, the 2class-MR approach resulted in less than -9% SUV bias in metastatic patients, demonstrating its potential to support quantitative SPECT imaging.
 
Keywords: SPECT, attenuation correction, quantitative imaging, MR.
Full-Text [PDF 1732 kb]   (849 Downloads)    
Type of Study: Original Research | Subject: Medical Physics
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mostafapour S, Arabi H, Gholamiankhah F, Razavi-Ratki S, Parach A. Tc-99m (methylene diphosphonate) SPECT quantitative imaging: Impact of attenuation map generation from SPECT-non-attenuation corrected and MR images on the diagnosis of bone metastasis. Int J Radiat Res 2021; 19 (2) :299-308
URL: http://ijrr.com/article-1-3644-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 2 (4-2021) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4645