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A comparative study of radioprotection by four Indian medicinal herbs against genotoxicity induced by sub-lethal gamma irradiation in Swiss albino mice
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M.R. Adhvaryu   , S.P. Srivastav , S.N. Vaniawala , M.N. Reddy |
| , meghna.adhvaryu@gmail.com |
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Abstract: (42216 Views) |
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Background: Synthetic radio-protective agents like
aminothiols are toxic and FDA approved agent
amifostine is no exception. Some Ayurvedic herbs have
shown radioprotective potential. This study was carried
out to test and compare the radioprotective potential
of Curcuma longa (CL) Tinospora cordifolia (TC),
Zizyphus mauritiana (ZM) and Ocimum sanctum (OS)
against 2Gy gamma irradiation in Swiss albino mice.
Materials and Methods: Adult Swiss albino mice
from random breed colony were divided in to 6 groups
(n=9), sham-control (SCT), radiation control (RACT),
and four herb + radiation groups respectively. All
except SCT were exposed to whole body 2 Gy of
gamma radiation in a teletherapy unit and SCT was
sham exposed on day 7 of herb pretreatment
(200mg/kg-bw orally by gavage). Chromosomal
studies from the bone marrow of femur by routine
metaphase preparation after colchicine treatment
were done in 3 animals from each group at 24, 72 and
168 hours after exposure. Results: All four herbs
showed significant radio-protective effects at 24 hrs.
OS, TC and ZM showed nearly similar activity while CL
showing the lowest activity. However the effects at 72
and 168 hrs showed highest protection by CL followed
by ZM |“| TC > OS respectively suggesting that the well
studied OS was less effective at 72 and 168 hrs.
Conclusion: All the four herbs showed radioprotective
potential with different efficacies at
different time interval. Iran. J. Radiat. Res., 2008 6 (1): 19-
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| Keywords: Radioprotection, chromosomal-damage, curcuma longa, ocimum sanctum, tinospora cordifolia, zizyphus mauritiana. |
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Full-Text [PDF 519 kb]
(4302 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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