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:: Volume 20, Issue 3 (7-2022) ::
Int J Radiat Res 2022, 20(3): 687-692 Back to browse issues page
Safety of daily fractionated thoracic radiosurgery
M. Kong, Y.J. Lim
Department of Radiation Oncology, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea , kongmoonkyoo@khu.ac.kr
Abstract:   (157 Views)
Background: The optimal inter-fraction interval in fractionated thoracic radiosurgery remains unclear. Several institutions maintain at least a 48-hour interval between each radiosurgery fraction. However, evidence supporting such radiosurgery schedule is lacking. Since 2014, we have performed daily fractionated thoracic radiosurgery without interruption. In this study, we evaluated the safety of daily administration of fractionated thoracic radiosurgery in patients with primary or metastatic lung cancer. Materials and methods: Patients who received radical or salvage fractionated radiosurgery for treatment of primary or metastatic lung cancer were included in this study. All patients received fractionated radiosurgery divided into 2-4 fractions administered daily without interruption. Radiosurgery-induced toxicities were evaluated. Results: Eighty-eight patients and 94 lung masses were treated. Radiosurgery-induced leukopenia and grade 5 toxicity did not occur. One patient experienced radiosurgery-induced grade 4 pneumonitis and dyspnea. Grade 3 pneumonitis, dyspnea, and fatigue developed in 23 (24.5%), 2 (2.1%), and 2 (2.1%) patients, respectively. Four (4.3%) patients experienced rib fracture. Dyspnea, fatigue, nausea, and pneumonitis were more common and severe in patients with central lung lesions. In contrast, dermatitis and rib fracture developed only in patients with peripheral lung lesions. Conclusions: Daily fractionated radiosurgery is safe and well-tolerated in patients with primary or metastatic lung cancer. For patient convenience and better treatment outcomes, daily-fractionated thoracic radiosurgery can be considered.
Keywords: Dose fractionation, lung neoplasm, radiosurgery, safety, toxicity.
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Type of Study: Original Research | Subject: Radiation Biology
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Kong M, Lim Y. Safety of daily fractionated thoracic radiosurgery. Int J Radiat Res. 2022; 20 (3) :687-692
URL: http://ijrr.com/article-1-4364-en.html


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Volume 20, Issue 3 (7-2022) Back to browse issues page
International Journal of Radiation Research
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