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:: Volume 20, Issue 4 (10-2022) ::
Int J Radiat Res 2022, 20(4): 761-765 Back to browse issues page
Assessment of vital organ dose in volumetric intensity modulated arc therapy for left and right breast cancer
H. Zhang , H. Yin , W. Shao
Abstract:   (899 Views)
Background: Breast cancer (BC) is a global threat to women’s health. Volumetric intensity modulated arc therapy (VMAT) is effective for the local control of BC. This study evaluated the pulmonary and cardiac radiotherapeutic dosage to provide information for estimating normal tissue complication probability (NTCP) once malignant tumors appear in patients’ left and right breasts. Materials and Methods: We conducted a retrospective analysis of VMAT regimen of 40 patients with BC, among whom 20 patients (group 1) were diagnosed with right BC and 20 patients (group 2) with left BC. The pulmonary and cardiac dose volume histogram (DVH) parameters were acquired and compared between patients with left and right BC treated with VMAT. Results: Generally, the pulmonary and cardiac dosages in patients with right BC were larger than in those with left BC. For the lung, the V20 and V5 of right BC patients were significantly higher, relative to the left BC patients (P<0.05). For the heart, the V5 and V10 of right BC patients were significantly lower, compared to left BC patients, with differences of up to 20% and 10%, respectively (both P<0.05). V20, V30, and V40 as low as zero were observed for right BC patients. Conclusions: When treating left BC, image guidance and respiratory management techniques should be applied to limit radiotherapy complications that occur in the heart because of patient positioning and respiratory movement.
Keywords: Left breast cancer, right breast cancer, VMAT, heart dose, lung dose.
Full-Text [PDF 1531 kb]   (525 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
1. Waks AG and Winer EP (2019) Breast Cancer Treatment: A Review. JAMA, 22; 321(3): 288-300. [DOI:10.1001/jama.2018.19323] [PMID]
2. Momenimovahed Z and Salehiniya H (2019) Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer, 11: 151-164. [DOI:10.2147/BCTT.S176070] [PMID] []
3. Lei S, Zheng R, Zhang S, et al. (2021) Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020. Cancer Communications, 41(11): 1183-1194. [DOI:10.1002/cac2.12207] [PMID] []
4. Chlebowski RT, Anderson GL, Aragaki AK, Manson JE, Stefanick ML, Pan K, et al. (2020) Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the women's health initiative randomized clinical trials. JAMA, 324(4): 369-380. [DOI:10.1001/jama.2020.9482] [PMID] []
5. Katalinic A, Eisemann N, Kraywinkel K, Noftz MR, Hübner J (2020) Breast cancer incidence and mortality before and after implementation of the German mammography screening program. Int J Cancer, 147(3): 709-718. [DOI:10.1002/ijc.32767] [PMID]
6. Mubari S, Malik SS, Wang Z, Li C, Fawad M, Yu C (2019) Recent insights into breast cancer incidence trends among four Asian countries using age-period-cohort model. Cancer Manag Res, 11: 8145-8155. [DOI:10.2147/CMAR.S208323] [PMID] []
7. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10801 women in 17 randomised trials. Lancet, 378(9804): 1707-1716. [DOI:10.1016/S0140-6736(11)61629-2] [PMID]
8. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med, 347(16): 1227-1232. [DOI:10.1056/NEJMoa020989] [PMID]
9. Veronesi U, Luini A, Vecchio M D, Greco M, Galimberti V, Merson M, et al. (1993) Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med, 328(22): 1587-1591. [DOI:10.1056/NEJM199306033282202] [PMID]
10. Cuzick J, Stewart H, Rutqvist L, Houghton J, Edwards R, Redmond C, et al. (1994) Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol, 12(3): 447-453. [DOI:10.1200/JCO.1994.12.3.447] [PMID]
11. Wolff D, Stieler F, Welzel G, Lorenz F, Abo-Madyan Y, Mai S, et al. (2009) Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer. Radiother Oncol, 93(2): 226-233. [DOI:10.1016/j.radonc.2009.08.011] [PMID]
12. Rao M, Yang W, Chen F, Sheng K, Ye J, Mehta V, et al. (2010) Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy. Med Phys, 37(3): 1350-1359. [DOI:10.1118/1.3326965] [PMID]
13. Hardcastle N, Tomé WA, Foo K, Miller A, Carolan M, Metcalfe P (2011) Comparison of prostate IMRT and VMAT biologically optimised treatment plans. Med Dosim, 36(3): 292-298. [DOI:10.1016/j.meddos.2010.06.001] [PMID] []
14. Chao PJ, Lee HF, Lan JH, Guo SS, Ting HM, Huang YJ, et al. (2017) Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT.Sci Rep, 7(1): 13771. [DOI:10.1038/s41598-017-14145-x] [PMID] []
15. Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever TD, Classic KL, et al. (2017) Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction. Am J Physiol Heart Circ Physiol, 313(2): H392-H407. [DOI:10.1152/ajpheart.00124.2017] [PMID] []
16. Ahn SH, Kim E, Kim C, Cheon W, Kim M, Lee SB, et al. (2021) Deep learning method for prediction of patient-specific dose distribution in breast cancer. Radiat Oncol, 16: 154. [DOI:10.1186/s13014-021-01864-9] [PMID] []
17. Qiu J, Zhang S, Lv B, Zheng X (2021) Cardiac dose control and optimization strategy for left breast cancer radiotherapy with non-uniform VMAT technology, Technol Cancer Res Treat, 20: 15330338211053752. [DOI:10.1177/15330338211053752] [PMID] []
18. Finazzi T, Nguyen VT, Zimmermann F, Papachristofilou A (2019) Impact of patient and treatment characteristics on heart and lung dose in adjuvant radiotherapy for left-sided breast cancer, Radiat Oncol, 14(1): 153. [DOI:10.1186/s13014-019-1364-3] [PMID] []
19. Ren W, Sun C, Lu N, Xu Y, Han F, Liu Y, et al. (2020) Dosimetric comparison of intensity-modulated radiotherapy, volumetric modulated arc therapy and hybrid three-dimensional conformal radiotherapy/intensity-modulated radiotherapy techniques for right breast cancer, J Clin Med, 9(12): 3884. [DOI:10.3390/jcm9123884] [PMID] []
20. Benedict SH, Yenice KM, Followill D, Galvin JM, Hinson W, Kavanagh B, et al. (2010) Stereotactic body radiation therapy: The report of AAPM Task Group101, Med Phys, 37(8): 4078-4101. [DOI:10.1118/1.3438081] [PMID]
21. Bradshaw PT, Stevens J, Khankari N, Teitelbaum SL, Neugut AI, Gammon MD (2016) Cardiovascular disease mortality among breast cancer survivors. Epi-demiology, 27(1): 6-13. [DOI:10.1097/EDE.0000000000000394] [PMID] []
22. Wijsman R, Dankers FJWM, Troost EGC, Hoffmann AL, van der Heijden EHFM, de Geus-Oei LF, et al. (2017) Inclusion of incidental radiation dose to the cardiac atria and ventricles does not improve the prediction of radiation pneumonitis in advanced-stage non-small cell lung cancer patients treated with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys, 99(2): 434-441. [DOI:10.1016/j.ijrobp.2017.04.011] [PMID]
23. Correa CR, Das IJ, Litt HI, Ferrari V, Hwang WT, Solin LJ, et al.(2008) Association between tangential beam treatment parameters and cardiac abnormalities after definitive radiation treatment for left-sided breast cancer. Int J Radiat Oncol Biol Phys, 72(2): 508-516. [DOI:10.1016/j.ijrobp.2007.12.037] [PMID]
24. Schultz-Hector S and Trott KR (2007) Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data[J].Int J Radiat Oncol Biol Phys, 67(1): 10-18. [DOI:10.1016/j.ijrobp.2006.08.071] [PMID]
25. Kaidar-Person O, Zagar TM, Oldan JD, Matney J, Jones EL, Das S, et al. (2017) Early cardiac perfusion defects after left-sided radiation therapy for breast cancer: is there a volume response. Breast Cancer Res Treat, 164(2): 253-262. [DOI:10.1007/s10549-017-4248-y] [PMID]
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Zhang H, Yin H, Shao W. Assessment of vital organ dose in volumetric intensity modulated arc therapy for left and right breast cancer. Int J Radiat Res 2022; 20 (4) :761-765
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Volume 20, Issue 4 (10-2022) Back to browse issues page
International Journal of Radiation Research
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