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Intratumoral injection of radioactive Astatine (211At) microspheres for the treatment of tumors
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Y. Li   , F. Pang , H. Cai , L. Li |
| Department of Nuclear Medicine, West China Hospital of Sichuan University, China , tsflyh@126.com |
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Abstract: (1025 Views) |
Background: Our aims were to prepare microspheres labelled with radioactive astatine as brachytherapy seeds and to confirm the antitumor ability of these microspheres. Materials and Methods: Chitosan-collagen composite microspheres (CCMs) were synthesized through an emulsification crosslink reaction and radiolabelled with 211At using the chloramine-T method. Radiation stability was assessed in both phosphate-buffered saline and blood serum. The in vivo distribution and therapeutic effects were evaluated in BALB/c nude mice with implanted tumours. Results: CCMs showed ideal morphological characteristics (diameter of 7.5-15 μm) and acceptable radiation stability (73.99% in PBS and 72.56% in serum after 16 hours). The in vivo biodistribution analysis demonstrated that 211At-CCMs were highly localized in tumour tissue. The therapeutic efficacy of 211At-CCMs when intratumorally injected into a cervical tumour model was assessed. Fourteen days after a single-dose treatment with 211At-CCMs, significantly retarded tumour volume growth was observed. Conclusion: 211At-CCM brachytherapy has the potential to provide an alternative solution for tumour treatment.
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| Keywords: Brachytherapy, microspheres, radiation oncology, Astatine-211. |
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Full-Text [PDF 2322 kb]
(688 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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Li Y, Pang F, Cai H, Li L. Intratumoral injection of radioactive Astatine (211At) microspheres for the treatment of tumors. Int J Radiat Res 2022; 20 (4) :793-798 URL: http://ijrr.com/article-1-4466-en.html
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