[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 20, Issue 4 (10-2022) ::
Int J Radiat Res 2022, 20(4): 851-855 Back to browse issues page
Modulatory effects of Zn oxide nanoparticles on cardiotoxicity and hematological changes in irradiated rats
M.M. Abbas , A.H. Mahmoud , H.A. Abdelmonem
Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt , dr.manammounir2021@yahoo.com
Abstract:   (739 Views)
Background: Cardiotoxicity is one of the most serious complications of radiation. Nanoparticles, has gained increasing attention as therapeutic agents. This work aims to evaluate the beneficial effect of zinc oxide nanoparticles (ZnONPs) on the cardiotoxicity induced by ionizing radiation. Materials and Methods: Twenty eight male rats were included in the study. Animals were categorized into four groups (n=7),  group I: (control), group II: rats were irradiated with a single dose of ɤ radiation (6Gy), group III: rats injected with ZnONPs (10mg /Kg b.wt), intrapritoneally for two weeks (5days/week), group IV (treated):  irradiated rats received ZnONPs intrapritoneally with the same dose for two weeks after 24hr of irradiation. Results: γ-irradiation caused a significant elevation in the levels of creatine phosphokinase, creatine kinase, lactate dehydrogenase, troponin I, fibrinogen and C-reactive protein. Additionally, a noticeable increase in the lipid content including cholesterol, triglycerides and low density lipoprotein with concomitant decline in high density lipoprotein and finally, a marked decrease in hematological parameters as compared to the control group. These changes manifested good amelioration in the groups injected with ZnONPs. Conclusion: Based on these findings, it can be argued that treatment with ZnONPs reduces the extent of radiation damage by providing significant hypolipidemic, anti-inflammatory and antioxidant effects in irradiated rats.
Keywords: Gamma irradiation, Zn oxide nanoparticles, cardiotoxicity.
Full-Text [PDF 546 kb]   (804 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. Thabet NM, Abdel-Rafei MK, Moustafa EM (2020) Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats. Role of hepatic PPAR-α/ P38 and cardiac Calcineurin-A/NFATc1/P38 pathways. Archives of Physiology and Biochemistry, 1-19. [DOI:10.1080/13813455.2020.1727526] [PMID]
2. Slezak J, Kura B, Babal P, Barancik M, Ferko M, Frimmel K, et al. (2017) Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury. Canadian Journal of Physiology and Pharmacology, 95: 1190-203. [DOI:10.1139/cjpp-2017-0121] [PMID]
3. Ping Z, Peng Y, Lang H, et al. (2020) Oxidative stress in radiation-induced cardiotoxicity. Oxid Med Cell Longev, 7: 1-15. [DOI:10.1155/2020/3579143] [PMID] []
4. Tan B, Norhaizan M, Liew W, et al. (2018) Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol, 24(9): 1-28. [DOI:10.3389/fphar.2018.01162] [PMID] []
5. Lee PJ and Mallik R (2005) Cardiovascular effects of radiation therapy: practical approach to radiation therapy-induced heart disease. Cardiol Rev, 13: 80-6. [DOI:10.1097/01.crd.0000131188.41589.c5] [PMID]
6. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. (2013) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med, 368: 987-98. [DOI:10.1056/NEJMoa1209825] [PMID]
7. Davis M and Witteles RM (2014) Radiation-induced heart disease: an under-recognized entity? Curr Treat Options Cardiovasc Med, 16: 317. [DOI:10.1007/s11936-014-0317-2] [PMID]
8. Andratschke N, Maurer J, Molls M, Trott KR (2011) Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol, 100: 160-6. [DOI:10.1016/j.radonc.2010.08.010] [PMID]
9. Timmis A, Gale CP, Flather M, Maniadakis N, Vardas P (2018) Cardiovascular disease statistics from the European atlas: inequalities between highand middle-income member countries of the ESC. Eur Soc Cardiol, 4(1): 1-3. [DOI:10.1093/ehjqcco/qcx045] [PMID]
10. Dweck MR, Doris MK, Motwani M, Adamson PD, Slomka P, Dey D, et al. (2016) Imaging of coronary atherosclerosis-evolution towards new treatment strategies. Nature Reviews Cardiology, 13: 533-48. 7. [DOI:10.1038/nrcardio.2016.79] [PMID]
11. Li T, Liang W, Xiao X, Qian Y (2018) Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases. Int J Nanomedicine , 5-v1228"(13): 349-362. [DOI:10.2147/IJN.S179678] [PMID] []
12. Mishra PK, Mishra H, Ekielski A, Talegaonkar S, Vaidya B (2017) Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications. Drug Discovery Today, 22(12): 1825-1834. [DOI:10.1016/j.drudis.2017.08.006] [PMID]
13. Smijs TG and Pavel S (2011) Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. Nanotechnology, Science and Applications, 4: 95-112. [DOI:10.2147/NSA.S19419] [PMID] []
14. Ruszkiewicz JA, Pinkas A, Ferrer B, Peres TV, Tsatsakis A, Aschner M (2017) Neurotoxic effect of active ingredients in sunscreen products, a contemporary review.Toxicology Reports, 4: 245-25. [DOI:10.1016/j.toxrep.2017.05.006] [PMID] []
15. Padmavathy N and Vijayaraghavan R (2008) Enhanced bioactivity of ZnO nanoparticles-an antimicrobial study. Sci Technol Adv Mater, 9(3): 035004. [DOI:10.1088/1468-6996/9/3/035004] [PMID] []
16. El-Gharbawy RM, Emara AM, Abu-Risha SE (2016) Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in Type-2 diabetes. Biomed Pharmacother, 84: 810-820. [DOI:10.1016/j.biopha.2016.09.068] [PMID]
17. Afifi M and Abdelazim AM (2015) Ameliorative effect of zinc oxide and silver nanoparticles on antioxidant system in the brain of diabetic rats. Asian Pac J Trop Biomed, 5(10): 874-877. [DOI:10.1016/j.apjtb.2015.06.010]
18. Afifi M, Almaghrabi, OA, Kadasa NM (2015) Ameliorative effect of zinc oxide nanoparticles on antioxidants and sperm characteristics in Streptozotocin-induced diabetic rat testes. Biomed Res Int, 1-6. [DOI:10.1155/2015/153573] [PMID] []
19. Nefissa H, Amal M, Ammal M, Zeinab A (2017) The protective effect of L-carnitine against gamma irradiation-induced cardiotoxicity in male albino rats. Egypt Acad J Biolog Sci, 9(2): 9-20. [DOI:10.21608/eajbsc.2017.13663]
20. Asri-Rezaei S, Dalir-Naghadeh B, Nazarizadeh A, Noori-Sabzikar Z (2017) Comparative study of cardio-protective effects of zinc oxide nanoparticles and zinc sulfate in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol, 42: 129-141. [DOI:10.1016/j.jtemb.2017.04.013] [PMID]
21. Bashandy SAE, Abdulaziz A, Sherif A, Abdelmottaleb M , Enayat AO (2018) Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats. Can J Physiol Pharmacol, 96: 337-344. [DOI:10.1139/cjpp-2017-0247] [PMID]
22. Friedwald WT, Levy RI, Fredrickson D (1972) Estimation of concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem, 18: 499. [DOI:10.1093/clinchem/18.6.499]
23. Borek C (1997) Antioxidants and cancer. Sci Med, 4: 51- 62.
24. Younis NK, Ghoubaira JA, Bassil EP, Tantawi HN, Ali HE (2021) Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases Nanomedicine. Nanotechnology Biology and Medicine, 36: 102433. [DOI:10.1016/j.nano.2021.102433] [PMID]
25. Sridharan, S and Shyamaladevi CS (2002) Protective effect of N-acetylcysteine against gamma ray induced damages in rats' biochemical evaluations. Indian J Exp Biol, 40: 181-186.
26. Abdel Magied N and Shedid SM (2020) Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats. Environmental Toxicology, 35(4): 430-442. [DOI:10.1002/tox.22879] [PMID]
27. Kermanshahi RK, Hojati V, Shiravi A (2015) Zinc oxide nanoparticles absorption rate in the heart tissue of female mice. J Chem Health Risk, 5(3): 193-198.
28. Koc M, Toysi S, Buykokuroglu ME, Bakan N (2003) Melatonin protects rat liver against irradiation induced oxidative injury. J Radiat Res, 44(3): 211-215. [DOI:10.1269/jrr.44.211] [PMID]
29. Prasad AS and Bao B (2019) Molecular mechanisms of zinc as a pro-antioxidant mediator: clinical therapeutic implications. Antioxidants (Basel), 8(6): E164. [DOI:10.3390/antiox8060164] [PMID] []
30. Gammoh NZ (2017) Rink L. Zinc in infection and inflammation. Nutrients, 9(6): 624. [DOI:10.3390/nu9060624] [PMID] []
31. Gharib OA (2007) Does kombucha tea reduce the damage-induced by radiation exposure? Egypt J Rad Sci Applic, 20: 141-6.
32. Hemnani T and Parihar M (1998) Reactive oxygen species and oxidative DNA damage. Ind J Physiol Pharmacol, 42: 440-443.
33. Brown LF, Dvorak AM, Dvorak HF (1989) Leaky vessels, fibrin deposition, and fibrosis: a sequence of events common to solid tumors and to many other types of disease. Am Rev Respir Dis, 140: 1104-1107. [DOI:10.1164/ajrccm/140.4.1104] [PMID]
34. Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, De Mori R, et al. ( 2008) Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev, 22: 1747-1752. [DOI:10.1101/gad.465908] [PMID] []
35. Fu Z-L , Zhang S-Q , Yang XU, Chai Rong , Chen C, Ruan L , Li W (2018) Changes of fibrinogen in a mouse model of radiation-induced brain injury. Chinese J Tissue Engineer Res, 22(12): 1889-1894.
36. Madamanchi N and Runge M (2007) Mitochondrial dysfunction in atherosclerosis. Circ Res, 100: 460-5. [DOI:10.1161/01.RES.0000258450.44413.96] [PMID]
37. Garcia MV, Bayon DJE, Culebras FJM, Jorqurera PF, Garcia DF (1996) Hepatic metabolism of cholesterol. Nutr Hosp, 11: 37.
38. Khamis F and Roushdy MH (1991) Synergistic radioprotective action of imidazole and serotonin on serum and liver enzymes in rats. Arab J Nucl Sci Applic, 24: 19-36.
39. El-Missiry MA, Fayed TA, El-Sawy MR, El-Sayed AA (2007) Ameliorative effect of melatonin against gamma-irradiation-induced oxidative stress and tissue injury. Ecotoxicol Environ Saf, 66: 278-286. [DOI:10.1016/j.ecoenv.2006.03.008] [PMID]
40. Sud VK and Sekhon GS (1989) Blood flow through the human arterial system in the presence of a steady magnetic field. Phys Med Biol, 34: 795. [DOI:10.1088/0031-9155/34/7/001] [PMID]
41. Osman NN and Hamza RG (2013) Protective effect of carica papaya linn against? Radiation-induced tissue damage in rats. Arab J of Nucl Sci and Appli, 46(1): (305-312).
42. Chew B and Park J (2004) Carotenoid action on the immune response. J Nutr, 134: 25. [DOI:10.1093/jn/134.1.257S] [PMID]
43. El-Deeb AE, Abd El-Aleem IM, Abd El-Rahman AA (2006) The curative effect of some antioxidants on γ-irradiated rats. J Egypt Soc Toxicol, 35: 79-89.
44. Selim N (2010) Comparative study on the effect ofradiation on whole blood and isolated red blood cells. Romanian J Biophys, 20(2): 127-136.
45. Sharma R and Purohit RK (2012) Protective role of liv.52 against radiation and cadmium induced haematological changes in the Swiss albino mice. Int J Life Sc Bt & Pharm Res, 1(3): 114-123.
46. Manisha A, Purohit RK, Chakrawarti A, Basu A, Bhartiya KM (2011) Protective efficacy of Aloe vera against radiation and cadmium induced haematological changes in the Swiss albino mice. Advanced Biotech, 10(10): 44-47.
47. Hussien EM, Darwish MM, Ali SE (2007) Prophylactic role of combined treatment with Coenzyme Q 10 and Vitamin E against radiation in male rats. Egypt J Rad Sci Applic, 20(1): 181-194.
48. Nunia V and Goyal PK (2004) Prevention of gamma radiation induced anaemia in mice by diltiazem. J Radiat Res, 45: 11-17. [DOI:10.1269/jrr.45.11] [PMID]
49. Ramadan FL (2007) Evaluation of the synergistic effect of danazol and radiation exposure on some biochemical functions in female albino rats. Egypt. J of Hospit Med, 27: 255- 262. [DOI:10.21608/ejhm.2007.17727]
50. Powell SR (2000) The antioxidant properties of zinc. JNutr, 130(5S): 1447S -1454S. [DOI:10.1093/jn/130.5.1447S] [PMID]
51. Arthur BC (1998) Zinc, Insulin and Diabetes. J Am Coll Nutri, 17: 09-115. [DOI:10.1080/07315724.1998.10718735] [PMID]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abbas M, Mahmoud A, Abdelmonem H. Modulatory effects of Zn oxide nanoparticles on cardiotoxicity and hematological changes in irradiated rats. Int J Radiat Res 2022; 20 (4) :851-855
URL: http://ijrr.com/article-1-4491-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 4 (10-2022) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4657