[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
IJRR Information::
For Authors::
For Reviewers::
News & Events::
Web Mail::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Hard Copy 2322-3243
Online 2345-4229
Online Submission
Now you can send your articles to IJRR office using the article submission system.



:: Volume 20, Issue 4 (10-2022) ::
Int J Radiat Res 2022, 20(4): 887-892 Back to browse issues page
Proximal-type epithelioid sarcoma of the groin: Clinical experience and literature review
X. Hu , C. Zhang , K. Qian , R. Yu , T. Mei , J. Cai
Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China , jiong_cai@163.com
Abstract:   (787 Views)
Background: Epithelioid sarcoma (ES) is a rare soft tissue tumor that mainly occurs under the skin of the extremities. ES in the groin area may be easily misdiagnosed with undifferentiated pleomorphic sarcoma, leiomyosarcoma, rhabdomyosarcoma, and other mesenchymal tumors. Herein, we reported a single case of a patient with proximal-type epithelioid sarcoma of the groin, including its clinical and imaging findings. We also discussed some previously reported similar cases. Case Presentation: Our ES patient was a 24-year-old male who developed a subcutaneous nodule in the groin area 1 year before admission. After careful clinical and pathological examination, the patient was diagnosed with ES. He received chemotherapy (doxorubicin, ifosfamide plus cisplatin) and, later on, surgery. His symptoms improved, and he is still being followed up. In addition, we conducted a review of the literature and compared our data with 12 previously reported similar cases (including 17 patients with ES involving the groin). Conclusion: ES is a highly invasive tumor prone to metastasis and postoperative recurrence. Surgery seems to be the most effective treatment for ES. The effectiveness of auxiliary and radiotherapy needs to be confirmed by a large amount of data. A systematic understanding of the clinical and imaging features of ES in the groin area may help clinical and imaging doctors to correctly diagnose the disease.
Keywords: Epithelioid sarcoma, groin, mesenchymal tumor, case report.
Full-Text [PDF 1111 kb]   (834 Downloads)    
Type of Study: Case Report | Subject: Radiation Biology
1. Thway K, Jones RL, Noujaim J, Fisher C (2016) Epithelioid Sarcoma: Diagnostic Features and Genetics. Adv Anat Pathol, 23(1): 41-49. [DOI:10.1097/PAP.0000000000000102] [PMID]
2. Lualdi E, Modena P, Debiec-Rychter M, Pedeutour F, Teixeira MR, Facchinetti F, et al. (2004) Molecular cytogenetic characterization of proximal-type epithelioid sarcoma. Genes Chromosomes Cancer, 41(3): 283-290. [DOI:10.1002/gcc.20086] [PMID]
3. Modena P, Lualdi E, Facchinetti F, Galli L, Teixeira MR, Pilotti S, et al. (2005) SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res, 65(10): 4012-4019. [DOI:10.1158/0008-5472.CAN-04-3050] [PMID]
4. Armah HB and Parwani AV (2009) Epithelioid sarcoma. Arch Pathol Lab Med, 133(5): 814-819. [DOI:10.5858/133.5.814] [PMID]
5. Noujaim J, Thway K, Bajwa Z, Bajwa A, Maki RG, Jones RL, et al. (2015) Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy. Front Oncol, 5: 186. [DOI:10.3389/fonc.2015.00186] [PMID] []
6. Fukunaga M and Ushigome S (1999) Proximal-type epithelioid sarcoma in the pelvic soft tissues. APMIS, 107(3): 283-288. [DOI:10.1111/j.1699-0463.1999.tb01555.x] [PMID]
7. Elsamna ST, Amer K, Elkattawy O, Beebe KS (2020) Epithelioid sarcoma: half a century later. Acta Oncol, 59(1): 48-54. [DOI:10.1080/0284186X.2019.1659514] [PMID]
8. Mahajan A, Sen I, Hazra D, Agarwal S (2016) Management of Epithelioid Sarcoma of the Inguinal Region with Vascular Invasion. Indian J Surg, 78(4): 315-317. [DOI:10.1007/s12262-015-1401-x] [PMID] []
9. Irimura S, Nishimoto K, Kikuta K, Nakayama R, Susa M, Horiuchi K, et al. (2015) Successful Treatment with Pazopanib for Multiple Lung Metastases of Inguinal Epithelioid Sarcoma: A Case Report. Case Rep Oncol, 8(3): 378-384. [DOI:10.1159/000439427] [PMID] []
10. Kim JY, Chung S, Lee HB, Chung YK (2012) Proximal-type Epithelioid Sarcoma Arising in the Inguinal Area. Arch Plast Surg, 39(2): 177-179. [DOI:10.5999/aps.2012.39.2.177] [PMID] []
11. Rekhi B and Singh N (2016) Spectrum of cytopathologic features of epithelioid sarcoma in a series of 7 uncommon cases with immunohistochemical results, including loss of INI1/SMARCB1 in two test cases. Diagn Cytopathol, 44(7): 636-642. [DOI:10.1002/dc.23494] [PMID]
12. Fujiki M, Miyamoto S, Arikawa M, Sakuraba M (2015) Combined Use of Anterolateral Thigh and Gluteal Fold Flaps for Complex Groin Reconstruction. Plast Reconstr Surg Glob Open, 3(10): e541. [DOI:10.1097/GOX.0000000000000525] [PMID] []
13. Dainichi T, Honma Y, Hashimoto T, Furue M (2008) Clavus detected incidentally by positron emission tomography with computed tomography. J Dermatol, 35(4): 242-243. [DOI:10.1111/j.1346-8138.2008.00454.x] [PMID]
14. Flucke U, Hulsebos TJ, van Krieken JH, Mentzel T (2010) Myxoid epithelioid sarcoma: a diagnostic challenge. A report on six cases. Histopathology, 57(5): 753-759. [DOI:10.1111/j.1365-2559.2010.03688.x] [PMID]
15. Rekhi B, Verma A, Jambhekar NA, Menon S, Laskar S, Merchant N, et al. (2016) Osteoclast-rich, proximal-type epithelioid sarcoma: clinicopathologic features of 3 unusual cases expanding the histomorphological spectrum. Ann Diagn Pathol, 21: 39-43. [DOI:10.1016/j.anndiagpath.2015.12.003] [PMID]
16. Khazeni K, LaBove H, Wilky B, Rosenberg AE, Paulus E, Chim H, et al. (2018) Myoepithelial carcinoma or epithelioid sarcoma - A rare diagnosis with poor prognosis. A case report and review of literature. Int J Surg Case Rep, 49: 239-243. [DOI:10.1016/j.ijscr.2018.06.016] [PMID] []
17. Mannan AA, Rifaat AA, Kahvic M, Kapila K, Mallik M, Grover VK, et al. (2010) Proximal-type epithelioid sarcoma in the groin presenting as a diagnostic dilemma. Pathol Oncol Res, 16(2): 181-188. [DOI:10.1007/s12253-009-9203-8] [PMID]
18. Hasegawa T, Matsuno Y, Shimoda T, Umeda T, Yokoyama R, Hirohashi S (2001) Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases. Mod Pathol, 14(7): 655-663. [DOI:10.1038/modpathol.3880368] [PMID]
19. Kodet R, Smelhaus V, Newton WA Jr, Hamoudi AB, Qualman SJ, Singley C, et al. (1994) Epithelioid sarcoma in childhood: An immunohistochemical, electron microscopic, and clinicopathologic study of 11 cases under 15 years of age and review of the literature. Pediatr Pathol, 14(3): 433-451. [DOI:10.3109/15513819409024274] [PMID]
20. Tateishi U, Hasegawa T, Kusumoto M, Yokoyama R, Moriyama N (2002) Radiologic manifestations of proximal-type epithelioid sarcoma of the soft tissues. AJR Am J Roentgenol, 179(4): 973-977. [DOI:10.2214/ajr.179.4.1790973] [PMID]
21. Chase DR and Enzinger FM (1985) Epithelioid sarcoma: Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol, 9(4): 241-263. [DOI:10.1097/00000478-198504000-00001]
22. Skubitz KM, Dadamo DR (2007) Sarcoma. Mayo Clin Proc, 82(11): 1409-1432. [DOI:10.4065/82.11.1409] [PMID]
23. Deng LW (2016) Clinical characteristic and CT features in trunk rhabdomyosarcoma. Southern Med Univ, 28: 21-56.
24. Girish G, Finlay K, Fessell D, Pai D, Dong Q, Jamadar D (2012) Imaging review of skeletal tumors of the pelvis malignant tumors and tumor mimics. ScientificWorldJournal, 2012: 240281. https://doi.org/10.1100/2012/240281 [DOI:10.1100/2012/290930] [PMID] []
25. Hain KS, Pickhardt PJ, Lubner MG, Menias CO, Bhalla S (2013) Presacral masses: multimodality imaging of a multidisciplinary space. Radiographics, 33(4): 1145-1167. [DOI:10.1148/rg.334115171] [PMID]
26. Zhou J, Ding J, Zeng M (2013) Relationship between imaging findings and pathology of primary chondrosarcoma. Radiology practice, 33(2): 1145-1167.
27. Colombo F, Franceschelli A, Schiavina R, Gentile G, Passaretti G, Martorana G (2013) Epithelioid sarcoma of the penis: a case report. J Sex Med, 10(11):2871-2874. [DOI:10.1111/j.1743-6109.2012.02774.x] [PMID]
28. Wolf PS, Flum DR, Tanas MR, Rubin BP, Mann GN (2008) Epithelioid sarcoma: the University of Washington experience. Am J Surg, 196(3): 407-412. [DOI:10.1016/j.amjsurg.2007.07.029] [PMID]
29. Levy A, Le Péchoux C, Terrier P, Bouaita R, Domont J, Mir O, et al. (2014) Epithelioid sarcoma: need for a multimodal approach to maximize the chances of curative conservative treatment. Ann Surg Oncol, 21(1): 269-276. [DOI:10.1245/s10434-013-3247-4] [PMID]
30. Baratti D, Pennacchioli E, Casali PG, Bertulli R, Lozza L, Olmi P, et al. (2007) Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol, 14(12): 3542-3551. [DOI:10.1245/s10434-007-9628-9] [PMID]
31. Gounder M, Schöffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, et al. (2020) Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol, 21(11): 1423-1432. [DOI:10.1016/S1470-2045(20)30451-4]
32. Tansir G, Rastogi S, Shamim SA, Barwad A (2021) Early clinical and metabolic response to tazemetostat in advanced relapsed INI1 negative epithelioid sarcoma. Future Sci OA, 7(4): FSO675. [DOI:10.2144/fsoa-2020-0173] [PMID] []
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hu X, Zhang C, Qian K, Yu R, Mei T, Cai J. Proximal-type epithelioid sarcoma of the groin: Clinical experience and literature review. Int J Radiat Res 2022; 20 (4) :887-892
URL: http://ijrr.com/article-1-4498-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 4 (10-2022) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4657