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The effect of radiotherapy and surgery on stage IIIA/B NSCLC patients treated with chemotherapy
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Y. Zeng   , G. Wang , H. Zheng , Y. Wang , G. Ma , Z. Pang , J. Du |
| Institute of Oncology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China , dujiajun@sdu.edu.cn |
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Abstract: (910 Views) |
Background: The combination of radiotherapy and surgery is used to treat locally advanced non-small cell lung cancer (NSCLC). The aim of this study was to analyze IIIA/B NSCLC patients treated with chemotherapy from the Surveillance, Epidemiology, and End Results (SEER) database to clarify whether patient prognosis correlated with surgery and radiotherapy. Materials and Methods: The IIIA/B NSCLC patients were selected from the SEER database and classified into IIIA (N0-1), IIIA (N2), IIIB (N2), and IIIB (N3). Cox analyses and Kaplan–Meier method were used to estimate the prognostic factors and lung cancer specific survival (LCSS) curves. Results: We divided 7933 cases into IIIA (N0-1), IIIA (N2), IIIB (N2), and IIIB (N3). Cox regression showed that age, sex, primary site, grade, treatment, T stage, and marriage were independent risk factors for IIIA (N0-1); age, sex, treatment, and T stage had prognostic significance for IIIA (N2); age, sex, primary site, grade, treatment, and T stage were prognostic factors for IIIB (N2); and age and primary site had effect on the prognosis of IIIB(N3). The effect of chemotherapy-surgery was better than that of chemotherapy-preoperative radiotherapy-surgery and chemotherapy-surgery-postoperative radiotherapy for IIIA (N0-1). In IIIA (N2) and IIIB, radiotherapy did not improve the LCSS. Conclusion: Surgery offered more survival benefits for IIIA (N0-1) patients. Radiotherapy did not improve the LCSS of IIIA (N2) and IIIB patients. |
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| Keywords: Surgery, radiotherapy, NSCLC, prognosis, chemotherapy. |
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Full-Text [PDF 1137 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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Zeng Y, Wang G, Zheng H, Wang Y, Ma G, Pang Z et al . The effect of radiotherapy and surgery on stage IIIA/B NSCLC patients treated with chemotherapy. Int J Radiat Res 2023; 21 (3) :475-483 URL: http://ijrr.com/article-1-4873-en.html
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