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:: Volume 21, Issue 3 (6-2023) ::
Int J Radiat Res 2023, 21(3): 561-569 Back to browse issues page
Dosimetric comparison of volumetric-modulated arc therapy (VMAT) and fixed field intensity-modulated radiotherapy (IMRT) in patients with nasal tumor: a meta-analysis
W.G. Feng , W. Ma , Sh.P. Li , Y.X. Guo , W. Du , H.Y. Cai
Department of Radiotherapy, Gansu Provincial Hospital, Lanzhou, Gansu 73000, China , gschy333@163.com
Abstract:   (933 Views)
Background: In recent years, volumetric-modulated arc therapy (VMAT) and fixed field intensity-modulated radiotherapy (IMRT) have been used as the two mainstream radiotherapy techniques for the treatment of nasal tumors. In this study, we compared effectiveness of these two radiotherapy techniques in the treatment of nasal tumors through analysis of relevant literature and meta-analysis. Materials and Methods: A search was performed on PubMed, Web of Science, Embase, and Cochrane Library databases on April 2022 to identify all related literature in line with pre-determined eligibility criteria. The included/excluded studies were screened manually and relevance data were extracted. Forest plots were plotted and analyze, Egger’s asymmetry tests and sensitivity analysis were conducted using software Stata 16.0. Results: Eight studies were included in the meta-analysis. We found no significant difference in D2% and D98% of the Planning Target Volumes (PTV) between VMAT and IMRT. In contrast, the conformity index (CI) and the homogeneity index (HI) were significantly different between the two groups. Further analysis revealed no significant differences in dose sparing for all analyzed organs at risk (OARs) between VMAT and IMRT techniques. In addition, the monitor unit (MUs) of VMAT plan was significantly lower than that of the IMRT plan. Conclusions: VMAT has better local tumor control rate compared with IMRT, but it does not significantly reduce maximum dose (Dmax) or mean dose (Dmean) of OARs. We suggest that VMAT plan may be a better radiation therapy technology in the treatment of nasal tumors.
Keywords: Nasal tumor, VMAT, IMRT, meta-analysis.
Full-Text [PDF 2357 kb]   (627 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
1. Katz TS, Mendenhall WM, Morris CG, et al. (2002) Malignant tumors of the nasal cavity and paranasal sinuses. Head & Neck, 24(9): 821-829. [DOI:10.1002/hed.10143] [PMID]
2. Japan Lymphoma Radiation Therapy Group (2001) Localized aggressive non- Hodgkin's lymphoma a of the nasal cavity a survey by the Japan Lymphonma a Radiation Therapy Group. Int J Radiat Oncol Biol Phys, 51(5): 1228-1233. [DOI:10.1016/S0360-3016(01)01800-4] [PMID]
3. Yao B, Li YX, Fang H, et al. (2006) Prognostic factors and treament outcome in early stage nasal NK/T cell lymphoma. Chin J Hematol, 27(4): 222-225.
4. Li H, Wang ChS, Wang XD (2014) Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China. Asian Pacific Journal of Cancer Prevention, 15: 2297-2302. [DOI:10.7314/APJCP.2014.15.5.2297] [PMID]
5. Tomita N, Kodaira T, Tachibana H, et al. (2009) A comparison of radiation treatment plans using IMRT with helical tomotherapy and 3D conformal radiotherapy for nasal natural killer/T-cell lymphoma. Br J Radiol, 82(981): 756-763. [DOI:10.1259/bjr/83758373] [PMID]
6. Mock U, Georg D, Bogner J, et al. (2004) Treatment planning comparison of conventional, 3D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys, 58(1): 147-154. [DOI:10.1016/S0360-3016(03)01452-4]
7. Liu X, Huang E, Wang Y, et al. (2017) Dosimetric comparison of helical tomotherapy, VMAT, fixed-field IMRT and 3D-conformal radiotherapy for stage I-II nasal natural killer T-cell lymphoma. Radiat Oncol, 12(1): 76. [DOI:10.1186/s13014-017-0812-1] [PMID] []
8. Paelinck L, Smedt BD, Reynaert N, et al. (2006) Comparison of dose-volume histograms of IMRT treatment plans for ethmoid sinus cancer computed by advanced treatment planning systems including Monte Carlo. Radiother Oncol, 81(3): 250-256. [DOI:10.1016/j.radonc.2006.10.023] [PMID]
9. Liu X, Yang Y, Jin F, et al. (2016) A comparison of volumetric modulated arc therapy and sliding-window intensity-modulated radiotherapy in the treatment of Stage I-II nasal natural killer/T-cell lymphoma. Med Dosim, 41(1): 42-46. [DOI:10.1016/j.meddos.2015.07.003] [PMID]
10. Ren W, Gao ShB, Yan J, et al. (2011) Comparison of the dosimetry of conventional three dimentional conformal intensity modulated radiation therapy for patients with nasal NK/T cell lymphoma. Chinese Clinical Oncology, 16(7): 644-647.
11. Lomax AJ, Goitein M, Adams J (2003) Intensity modulation in radiotherapy: photons versus protons in the paranasal sinus. Radiotherapy and Oncology, 66: 11-18. [DOI:10.1016/S0167-8140(02)00308-0] [PMID]
12. Dirix P, Vanstraelen B, Jorissen M, et al. (2010) Intensity-modulated radiotherapy for sinonasal cancer: improved outcome compared to conventional radiotherapy. Int J Radiat Oncol Biol Phys, 78(4): 998-1004. [DOI:10.1016/j.ijrobp.2009.09.067] [PMID]
13. Hounsell AR, Sharrock PJ, Moore CJ, et al. (1992) Computer-assisted generation of multi-leaf collimator settings for conformation therapy. The British Journal of Radiology, 65: 321-326. [DOI:10.1259/0007-1285-65-772-321] [PMID]
14. Chin LM, Kijewski PK, Svensson GK, Bjärngard BE (1983) Dose optimisation with computer-controlled gantry rotation, collimator motion and dose-rate variation. Int J Radiat Oncol Biol Phys, 9(5): 723-729. [DOI:10.1016/0360-3016(83)90241-9]
15. Sankaralingam M, Glegg M, Smith S, et al. (2012) Quantitative comparison of volumetric modulated arc therapy and intensity modulated radiotherapy plan quality in sino-nasal cancer. Journal of Medical Physics, 37(1): 8-13. [DOI:10.4103/0971-6203.92715] [PMID] []
16. Kathirvel M; Subramani V, Subramanian VS, et al.(2017) Dosimetric comparison of head and neck cancer patients planned with multivendor volumetric modulated arc therapy technology. Journal of Canser Research and Therapeutics, 13: 122-130. [DOI:10.4103/0973-1482.203600] [PMID]
17. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(7): e1000097. https://doi.org/10.1093/ptj/89.9.873 https://doi.org/10.1016/j.jclinepi.2009.06.005 https://doi.org/10.1371/journal.pmed.1000097 https://doi.org/10.7326/0003-4819-151-4-200908180-00135 https://doi.org/10.3736/jcim20090918 [DOI:10.1136/bmj.b2535]
18. Ning ZH, Jiang JT, Li XD, et al. (Published online 2014) (2015) Coplanar VMAT vs. noncoplanar VMAT in the treatment of sinonasal cancer. Strahlentherapie und Onkologie, 191(1): 34-42. [DOI:10.1007/s00066-014-0760-8] [PMID]
19. Sang Y, Shan G, Shao K, et al. (2020) Radiotherapy for maxillary sinus carcinoma: dosimetric comparison of volumetric modulated arc therapy with 0° and 90° collimator intensity modulated radiation therapy. Journal of Radiation Oncology, 9: 53-58. [DOI:10.1007/s13566-020-00422-2]
20. Raturi VP, Motegi A, Zenda S, et al. (2021) Comparison of a Hybrid IMRT/VMAT technique with non-coplanar VMAT and non-coplanar IMRT for unresectable olfactory neuroblastoma using the RayStation treatment planning system-EUD, NTCP and planning study. J Radiat Res, 62(3): 540-548. [DOI:10.1093/jrr/rrab010] [PMID] []
21. Nguyen K, Cummings D, Lanza VC, et al. (2013) A dosimetric comparative study: volumetric modulated arc therapy vs intensity-modulated radiation therapy in the treatment of nasal cavity carcinomas. Med Dosim, 38(3): 225-232. [DOI:10.1016/j.meddos.2013.01.006] [PMID]
22. Lu JY, Zheng J, Zhang WZ, Huang BT (2016) Flattening Filter-Free Beams in Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy for Sinonasal Cancer. PLoS One, 11(1): 1-11. [DOI:10.1371/journal.pone.0146604] [PMID] []
23. Liu X, Wu F, Guo Q, et al. (2019) Estimation of radiotherapy modalities for patients with stage I-II nasal natural killer T-Cell lymphoma. Cancer Manag Res, 11: 7219-7229. [DOI:10.2147/CMAR.S201514] [PMID] []
24. Jeong Y, Lee SW, Kwak J, et al. (2014) A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer. Radiat Oncol, 9: 193. [DOI:10.1186/1748-717X-9-193] [PMID] []
25. Çakir A and Akgün Z (2019) Comparison of anisotropic analytical algorithm and acuros XB calculation algorithms on intensity-modulated radiotherapy and volumetric modulated arc therapy techniques for nasal cavity and paranasal sinus tumors: Effects on integral radiation dose. Turk Onkoloji Dergisi, 34(4): 256-264. [DOI:10.5505/tjo.2019.2075]
26. Cai HY, Liu Y, Li ZH (2022) The efficacy and safety of proton, carbon ion and TOMO radiotherapy for esophageal cancer: A systematic review and meta-analysis. Asian Journal of Surgery, 45: 1311-1312. [DOI:10.1016/j.asjsur.2022.01.079] [PMID]
27. Zeng L, Chen LJ, Da DZ, Cai HY (2022) Primary squamous cell carcinoma of the thyroid: A systematic review. Asian Journal of Surgery, 45: 1016-1017. [DOI:10.1016/j.asjsur.2022.01.008] [PMID]
28. Ma W, Cai HY, Miao GY, et al. (2016) Postoperative radiotherapy and postoperative chemotherapy for patients with endometrial cnacer: a Meta-analysis. J Int Oncol, 43(11): 829-834.
29. Kim DH, Ki YK, Kim WT, Park D, Joo JH, Jeon HS, Nam JH (2022) Impact of postoperative neck radiotherapy on regional control in pathologically node -negative head and neck cancer: A meta -analysis. Int J Radiat Res, 22(2): 257-261. [DOI:10.52547/ijrr.20.2.1]
30. Zhou Y and Wang C (2022) The accurate diagnosis of grand microvascular imaging in differentiating benign and malignant thyroid nodules: A meta -analysis. Int J Radiat Res, 20(2): 263-267. [DOI:10.52547/ijrr.20.2.2]
31. ICRU 83 (2010) Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT):Contents. Journal of the ICRU, 10(1): 1-3. [DOI:10.1093/jicru_ndq002]
32. Kataria T, Sharma K, Subramani V, et al. (2012) Homogeneity Index: An objective tool for assessment of conformal radiation treatments. J Med Phys, 37(4): 207-213. [DOI:10.4103/0971-6203.103606] [PMID] []
33. Feuvret L, Noel G, Mazeron JJ, Bey P. (2006) Conformity index: a review. Int J Radiat Oncol Biol Phys, 64(2): 333-342. [DOI:10.1016/j.ijrobp.2005.09.028] [PMID]
34. Cheung FW and Law MY (2012) A novel conformity index for intensity modulated radiation therapy plan evaluation. Med Phys, 39(9): 5740-56. [DOI:10.1118/1.4742848] [PMID]
35. ICRU 83 (2010) Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT). Journal of the ICRU, 10(1): 29-33. [DOI:10.1093/jicru/ndq002]
36. Bai W, Kou C, Yu W, et al. (2018) Dosimetric comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy in patients with cervical cancer: a meta-analysis. Onco Targets Ther, 11: 7179-86. [DOI:10.2147/OTT.S178336] [PMID] []
37. Ren W, Sun C, Lu N, et al. (2016) Dosimetric comparison of intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy in patients with prostate cancer: a meta-analysis. J Appl Clin Med Phys, 17(6): 254-261. [DOI:10.1120/jacmp.v17i6.6464] [PMID] []
38. Rashid A, Ahmad Z, Memon MA, Hashim ASM (2021) Volumetric Modulated Arc Therapy (VMAT): A modern radiotherapy technique - A single institutional experience. Pak J Med Sci, 37(2): 355-361. [DOI:10.12669/pjms.37.2.2647] [PMID] []
39. Ma M, Ren W, Li M, Niu C, Dai J (2021) Dosimetric comparison of coplanar and noncoplanar beam arrangements for radiotherapy of patients with lung cancer: A meta-analysis. J Appl Clin Med Phys, 22(4): 34-43. [DOI:10.1002/acm2.13197] [PMID] []
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Feng W, Ma W, Li S, Guo Y, Du W, Cai H. Dosimetric comparison of volumetric-modulated arc therapy (VMAT) and fixed field intensity-modulated radiotherapy (IMRT) in patients with nasal tumor: a meta-analysis. Int J Radiat Res 2023; 21 (3) :561-569
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Volume 21, Issue 3 (6-2023) Back to browse issues page
International Journal of Radiation Research
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