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:: Volume 22, Issue 1 (1-2024) ::
Int J Radiat Res 2024, 22(1): 77-83 Back to browse issues page
Protective effect of irradiated-Ficus carica dried leaf against hepatic-damage induced by ethanol in male rats
A.A. Mansour , A.M. Abdul Azeem , A.N. El shahat , M.H.M. Abd el Megid
Food Irradiation Research Department, Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt , alyncrt @yahoo.com
Abstract:   (622 Views)
Background: This study aimed to evaluate the effects of gamma rays and electron beams (5kGy) on the chemical content of dried fig leaves. In addition, the hepatoprotective effect of irradiated-dried fig leaves powder (GFLP) against ethanol (EtOH)-induced hepatotoxicity in rats was investigated. Materials and Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, sugar, total phenolic, total flavonoid content, phytate, and tannin contents of either raw or irradiated dried fig leaves were detected in this study. For the experimental study, 28 male rats were divided into four groups; Group C, control; Group 2: received an oral dose of ethanol (0.5 ml/100 gm b.wt. /day /5 weeks) and Groups 3-4: rats fed daily (60 min after EtOH injection) on either raw or irradiated fig leaves powder (4% of the weight of the diet). Results: It was observed from the results that gamma-irradiation (5 kGy) resulted in a higher increase in DPPH radical scavenging activity, sugar, total phenolic and total flavonoid content, and a higher reduction in phytate and tannin contents than e-beam irradiation. The results of the experimental study revealed that treatment of EtOH-rats with GFLP resulted in a significant reduction in the serum blood alcohol level, the activity of some liver enzymes, level of tumor necrotic factor-alpha, interleukin-6, malondialdehyde, and lipid profile contents associated with significant elevation in the level of high-density lipoprotein-cholesterol, hepatic total antioxidant capacity and glutathione content relative to EtOH-group. Conclusion: The enhanced antioxidant activities of Ficus carica leaves through irradiation could be applied as a natural antioxidant source in foodstuff.
Keywords: Ficus carica, gamma irradiation, e-beam, ethanol.
Full-Text [PDF 579 kb]   (406 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Mansour A, Abdul Azeem A, El shahat A, Abd el Megid M. Protective effect of irradiated-Ficus carica dried leaf against hepatic-damage induced by ethanol in male rats. Int J Radiat Res 2024; 22 (1) :77-83
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Volume 22, Issue 1 (1-2024) Back to browse issues page
International Journal of Radiation Research
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