|
Application of ultrasonography and 99mTc-MIBI scintigraphy in the diagnosis and localization of hyperparathyroidism
|
Y. Luo   , C. Peng , Q. Deng , H. Song , S. Zhai , Q. Zhou |
| Department of Nuclear Medicine, Putuo People's Hospital, Tongji University, Shanghai, 200060, China , zhaishijunprm@163.com |
|
|
Abstract: (344 Views) |
Background: The To discuss the application value of ultrasonography (US) and 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy in hyperparathyroidism (HPT), so as to provide a more reliable guarantee for surgery or thermal ablation. Materials and Methods: Sixty-four HPT patients admitted to our hospital and the Tenth People's Hospital of Tongji University from January 2018 to February 2023 were selected as research participants. All patients underwent cervical US, dual-phase 99mTc-MIBI planar scintigraphy, single photon emission computed tomography (SPECT), and pathological examination. The diagnostic efficiency of the above three imaging modalities was evaluated with pathological findings as the gold standard. In addition, the influence of parathyroid position, size and histological type on imaging results was evaluated. Results: Among the 64 patients, 71 positive lesions were pathologically confirmed. The analysis showed that 99mTc-MIBI SPECT/CT (Kappa=0.806) and US (Kappa=0.686) had high consistency with pathological findings, while dual-phase 99mTc-MIBI planar scintigraphy had moderate consistency with pathological examination results (Kappa=0.594). Conclusions: 99mTc-MIBI scintigraphy can significantly improve the diagnostic rate of parathyroid lesions. US is first recommended for patients suspected of HPT, followed by 99mTc-MIBI scintigraphy for confirmation. |
|
| Keywords: Ultrasonography, 99mTc-MIBI, hyperparathyroidism, SPECT, CT |
|
|
Full-Text [PDF 571 kb]
(168 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| References |
1. Bilezikian JP, Bandeira L, Khan A, Cusano NE (2018) Hyperparathyroidism. Lancet, 391(10116): 168-178. [ DOI:10.1016/S0140-6736(17)31430-7] 2. Lau WL, Obi Y, Kalantar-Zadeh K (2018) Parathyroidectomy in the Management of Secondary Hyperparathyroidism. Clin J Am Soc Nephrol, 13(6): 952-961. [ DOI:10.2215/CJN.10390917] 3. Kowalski GJ, Buła G, Żądło D, et al. (2020) Primary hyperparathyroidism. Endokrynol Pol, 71(3): 260-270. [ DOI:10.5603/EP.a2020.0028] 4. Messa P and Alfieri CM (2019) Secondary and Tertiary Hyperparathyroidism. Front Horm Res, 51: 91-108. [ DOI:10.1159/000491041] 5. Muñoz-Torres M and García-Martín A (2018) Primary hyperparathyroidism. Hiperparatiroidismo primario. Med Clin (Barc), 150(6): 226-232. [ DOI:10.1016/j.medcli.2017.07.020] 6. Cusano NE, Cipriani C, Bilezikian JP (2018) Management of normocalcemic primary hyperparathyroidism. Best Pract Res Clin Endocrinol Metab, 32(6): 837-845. [ DOI:10.1016/j.beem.2018.09.009] 7. Mizobuchi M, Ogata H, Koiwa F (2019) Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment. Ther Apher Dial, 23(4): 309-318. [ DOI:10.1111/1744-9987.12772] 8. Blau JE and Simonds WF (2021) Familial hyperparathyroidism. Front Endocrinol (Lausanne), 12: 623667. [ DOI:10.3389/fendo.2021.623667] 9. Chen Z, Cheng L, Zhang W, He W (2022) Ultrasound-guided thermal ablation for hyperparathyroidism: current status and prospects. Int J Hyperthermia 39(1): 466-474. [ DOI:10.1080/02656736.2022.2028907] 10. Komek H, Yilmaz EE, Cakabay B, et al. (2018) Contrast enhanced [99mTc] MIBI SPECT/CT in primary hyperparathyroidism. Ann Ital Chir, 89: 379-384. 11. Newey PJ (2021) Hereditary Primary Hyperparathyroidism. Endocrinol Metab Clin North Am, 50(4): 663-681. [ DOI:10.1016/j.ecl.2021.08.003] 12. Masi L (2019) Primary hyperparathyroidism, Front Horm Res, 51: 1-12. [ DOI:10.1159/000491034] 13. Fuster D, Torregrosa JV, Domenech B, et al. (2009) Dual-phase 99mTc-MIBI scintigraphy to assess calcimimetic effect in patients on haemodialysis with secondary hyperparathyroidism. Nucl Med Commun, 30(11): 890-894. [ DOI:10.1097/MNM.0b013e3283305df6] 14. Caldarella C, Treglia G, Pontecorvi A, Giordano A (2021) Diagnostic performance of planar scintigraphy using ⁹⁹mTc-MIBI in patients with secondary hyperparathyroidism: a meta-analysis. Ann Nucl Med, 26(10): 794-803. [ DOI:10.1007/s12149-012-0643-y] 15. Li X, Li J, Li Y, et al. (2020) The role of preoperative ultrasound, contrast-enhanced ultrasound, and 99mTc-MIBI scanning with single-photon emission computed tomography/X-ray computed tomography localization in refractory secondary hyperparathyroidism. Clin Hemorheol Microcirc, 75(1): 35-46. [ DOI:10.3233/CH-190723] 16. Zarei A, Karthik S, Chowdhury FU, et al. (2022) Multimodality imaging in primary hyperparathyroidism. Clin Radiol, 77(6): e401-e416. [ DOI:10.1016/j.crad.2022.02.018] 17. Salhi H, Bouziane T, Maaroufi M, et al. (2022) Primary hyperparathyroidism: Correlation between cervical ultrasound and MIBI scan. Ann Afr Med, 21(2): 161-164. [ DOI:10.4103/aam.aam_73_20] 18. Liu F, Liu Y, Peng C, et al. (2022) Ultrasound-guided microwave and radiofrequency ablation for primary hyperparathyroidism: a prospective, multicenter study. Eur Radiol, 32(11): 7743-7754. [ DOI:10.1007/s00330-022-08851-y] 19. Zhao Q, Dong A, Zuo C, Yang B (2023) 99mTc-MIBI SPECT/CT in a case of renal oncocytosis. Clin Nucl Med, 10.1097/RLU.0000000000004775. [ DOI:10.1097/RLU.0000000000004775] 20. Li Q, Pan J, Luo Q, et al. (2015) The key role of 99mTc-MIBI SPECT/CT in the diagnosis of parathyroid adenoma: a case report. Arch Endocrinol Metab, 59(3): 265-9. [ DOI:10.1590/2359-3997000000048] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Luo Y, Peng C, Deng Q, Song H, Zhai S, Zhou Q. Application of ultrasonography and 99mTc-MIBI scintigraphy in the diagnosis and localization of hyperparathyroidism. Int J Radiat Res 2024; 22 (1) :97-101 URL: http://ijrr.com/article-1-5219-en.html
|
