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Gene expression in luminal A breast cancer and its correlation with chemoradiotherapy outcome and recurrence
J. Ma , T. Gan , A. Song
Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China , songail@lzu.edu.cn
Abstract:   (323 Views)
Background: Breast cancer is a common cancer that affects women. The Luminal A subtype of breast cancer is defined by low Ki67 expression (<14%), Her-2 negative, and positive ER and PR. Luminal A exhibits a favorable prognosis compared to other breast cancer types. Materials and Methods: Gene expression profiling was employed in this investigation to discover genes linked to clinical efficacy and recurrence in Luminal A breast cancer tissue samples. The study's overarching goal was to discover new therapeutic targets by deciphering the molecular mechanisms behind Luminal A breast cancer. Results: Our analysis revealed specific genes linked to Luminal A breast cancer, and their expression levels were correlated with clinical outcomes. High expression of certain genes was associated with improved clinical efficacy and a reduced recurrence rate. Conclusion: The study provides valuable insights into the molecular mechanisms of Luminal A breast cancer, offering potential targets for personalized therapeutic approaches.
Keywords: Breast neoplasms, luminal a subtype, gene expression, clinical efficacy, recurrence.
Full-Text [PDF 987 kb]   (19 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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International Journal of Radiation Research
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