[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 277-282 Back to browse issues page
Prognostic value and clinical relevance of tertiary lymphoid structures in non-muscle-invasive bladder cancer
JB. Ji , PC. Li , TT. Yuan , ZK. Qu , GX. Song , ML. Bao , XD. Liang , B. Jiang , XL. Yin , YY. Wang , H. Ji
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China , lipengchao_edu@outlook.com
Abstract:   (416 Views)
Background: The presence of tertiary lymphoid structures (TLS) is related with good prognosis of various cancers including bladder cancer. The majority of bladder tumors are identified as non-muscle-invasive bladder cancer (NMIBC) when they are discovered in their early stages. We aimed to evaluate the prognostic value and clinical relevance of TLS in NMIBC. Materials and Methods: This cohort included 130 NMIBC samples, with 39 (30%) having TLS, as confirmed by hematoxylin and eosin and immunohistochemistry staining. The chi-square test was utilized to examine the relationship between TLS and the biomarkers and clinicopathologic characteristics of NMIBC. Results: It was found that TLS has significant association with pT stage, Ki-67 expression, and COX-2 expression. Using Kaplan-Meier analysis and Gehan-Breslow-Wilcoxon test, we found that the presence of TLS is associated with longer recurrence-free survival and overall survival of NMIBC patients. Moreover, we used bioinformatics to analyze the association of TLS marker L1CAM and bladder cancer. L1CAM is downregulated in bladder cancer, linked to an advanced stage of the disease, and indicates a poorer prognosis for those who have bladder cancer. In bladder cancer, there is a positive correlation between its expression and B cell infiltration. We also indicated that NMIBC with TLS have a higher level of TLS than that without TLS. Conclusion: To conclude, the presence of TLS is an important favorable prognostic indicator in NMIBC. A further understanding on TLS can provide new insights to improve immunotherapy for bladder cancer.
Keywords: Tertiary lymphoid structure, non-muscle-invasive bladder cancer, clinical relevance.
Full-Text [PDF 732 kb]   (77 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Siegel RL, KD Miller, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin, 72(1): 7-33. [DOI:10.3322/caac.21708]
2. Dy GW, Gore JL, Forouzanfar MH, et al. (2017) Global Burden of Urologic Cancers, 1990-2013. Eur Urol, 71(3): 437-446. [DOI:10.1016/j.eururo.2016.10.008]
3. Amin MB, Greene FL, Edge SB, et al. (2017) The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin, 67(2): 93-99. [DOI:10.3322/caac.21388]
4. Avritscher EB, Cooksley CD, Grossman HB, et al. (2006) Clinical model of lifetime cost of treating bladder cancer and associated complications. Urology, 68(3): 549-53. [DOI:10.1016/j.urology.2006.03.062]
5. Kamat AM, Hahn NM, Efstathiou JA, et al. (2016) Bladder cancer. Lancet, 388(10061): 2796-2810. [DOI:10.1016/S0140-6736(16)30512-8]
6. Bhindi B, Kool R, Kulkarni GS, et al. (2021) Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer - Full-text. Can Urol Assoc J, 15(8): E424-e460. [DOI:10.5489/cuaj.7367]
7. Hiraoka N, Ino Y, Yamazaki-Itoh R (2016) Tertiary lymphoid organs in cancer tissues. Front Immunol, 7: 244. [DOI:10.3389/fimmu.2016.00244]
8. Meylan M, Petitprez F, Becht E, et al. (2022) Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer. Immunity, 55(3): 527-541.e5. [DOI:10.1016/j.immuni.2022.02.001]
9. Horeweg N, Workel HH, Loiero D, et al. (2022) Tertiary lymphoid structures critical for prognosis in endometrial cancer patients. Nat Commun, 13(1): 1373. [DOI:10.1038/s41467-022-29040-x]
10. Cabrita R, Lauss M, Sanna A, et al. (2020) Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature, 577(7791): 561-565. [DOI:10.1038/s41586-019-1914-8]
11. Patil NS, BY Nabet Müller S, et al. (2022) Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell, 40(3): 289-300.e4. [DOI:10.1016/j.ccell.2022.02.002]
12. Bai Z, Zhou Y, Ye Z, et al. (2021) Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy. Front Immunol, 2021. 12: p. 808964. [DOI:10.3389/fimmu.2021.808964]
13. Schumacher TN and Thommen DS (2022) Tertiary lymphoid structures in cancer. Science, 375(6576): eabf9419. [DOI:10.1126/science.abf9419]
14. Wang B, Liu J, Han Y, et al. (2022) The Presence of Tertiary Lymphoid Structures Provides New Insight Into the Clinicopathological Features and Prognosis of Patients With Breast Cancer. Front Immunol, 13: p. 868155. [DOI:10.3389/fimmu.2022.868155]
15. Fridman WH, Pagès F, Sautès-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer, 2012. 12(4): p. 298-306. [DOI:10.1038/nrc3245]
16. Koti M, Xu AS, Ren KYM, et al. (2017) Tertiary Lymphoid Structures Associate with Tumour Stage in Urothelial Bladder Cancer. Bladder Cancer, 3(4): 259-267. [DOI:10.3233/BLC-170120]
17. Lindskrog SV, Prip F, Lamy P, et al. (2021) An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer. Nat Commun, 12(1): 2301. [DOI:10.1038/s41467-021-22465-w]
18. Nielsen JS, Sahota RA, Milne K, et al. (2012) CD20+ tumor-infiltrating lymphocytes have an atypical CD27- memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer. Clin Cancer Res, 18(12): p. 3281-92. [DOI:10.1158/1078-0432.CCR-12-0234]
19. Kroeger DR, Milne K, BH Nelson (2016) tumor-infiltrating plasma cells Are associated with tertiary lymphoid structures, cytolytic T-cell responses, and superior prognosis in ovarian cancer. Clin Cancer Res, 22(12): 3005-15. [DOI:10.1158/1078-0432.CCR-15-2762]
20. Zhou L, Xu B, LiuY, Z. Wang (2021) Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer. Oncoimmunology, 10(1): 1915574. [DOI:10.1080/2162402X.2021.1915574]
21. An Y, Sun JX, Xu MY, et al. (2022) Tertiary lymphoid structure patterns aid in identification of tumor microenvironment infiltration and selection of therapeutic agents in bladder cancer. Front Immunol, 13: p. 1049884. [DOI:10.3389/fimmu.2022.1049884]
22. Faltas, BM, Prandi D, Tagawa ST, et al.(2016) Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nat Genet, 48(12): 1490-1499. [DOI:10.1038/ng.3692]
23. Hong H, Stastny M, Brown C, et al. (2014) Diverse solid tumors expressing a restricted epitope of L1-CAM can be targeted by chimeric antigen receptor redirected T lymphocytes. J Immunother, 37(2): 93-104. [DOI:10.1097/CJI.0000000000000018]
24. Culpan M, Turan T, Ozkanli SS, et al. (2021) Prognostic and clinicopathologic value of ki-67 and profilin 1 immunohistochemical expression in primary pT1 urothelial bladder cancer. J Cancer Res Ther, 17(2): 434-442. [DOI:10.4103/jcrt.JCRT_408_19]
25. Li D, Zhong S, Zhu Z, et al. (2020) LncRNA MAFG-AS1 promotes the progression of bladder cancer by targeting the miR-143-3p/COX-2 axis. Pathobiology, 87(6): 345-355. [DOI:10.1159/000509957]
26. Wan GX, Chen P, Yu XJ, et al. (2015) Cyclooxygenase-2 polymorphisms and bladder cancer risk: a meta-analysis based on case-control studies. Int J Clin Exp Med, 8(3): 3935-45.
27. Gakis G (2014) The role of inflammation in bladder cancer. Adv Exp Med Biol, 816: 183-96. [DOI:10.1007/978-3-0348-0837-8_8]
28. Groeneveld CS, Fontugne J, Cabel L, et al.(2021) Tertiary lymphoid structures marker CXCL13 is associated with better survival for patients with advanced-stage bladder cancer treated with immunotherapy. Eur J Cancer, 148: 181-189. [DOI:10.1016/j.ejca.2021.01.036]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ji J, Li P, Yuan T, Qu Z, Song G, Bao M, et al . Prognostic value and clinical relevance of tertiary lymphoid structures in non-muscle-invasive bladder cancer. Int J Radiat Res 2024; 22 (2) :277-282
URL: http://ijrr.com/article-1-5392-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.06 seconds with 50 queries by YEKTAWEB 4657