[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: ::
Back to the articles list Back to browse issues page
Diagnostic value of joint detection of serum tumor markers in different pathological types of lung cancer
W. Liu , D. Zang
Department of Clinical Laboratory, Beijing Hospital of Integrated Chinese & Western Medicine, Beijing 100039, China , lww16032810@163.com
Abstract:   (46 Views)
Background: To evaluate the diagnostic potential of joint testing of serum tumor markers containing cytokeratin fragment antigen 21-1 (CYFRA21-1), progastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA) as well as neuron-specific enolase (NSE) in a variety oflung cancer (LC). Materials and Methods: The LC group comprised 150 LC patients who were diagnosed for the first time and were not treated. During the same period, 120 patients harbored benign lung diseases and 120 healthy subjects were respectively designated as the benign group and control group. Immunochemiluminescence assay was implemented to detect tumor markers in serum from three groups and different types of LC. Results: Levels of four serum tumor markers in LC group were elevated relative to control group. CYFRA21-1 level in lung squamous cell carcinoma (LSCC) group was elevated compared to lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) groups. ProGRP and NSE levels in SCLC group increased compared to LSCC and LUAD groups. CEA level in LUAD group was higher compared to LSCC and SCLC groups. The highest positive rate of LSCC was CYFRA21-1, the highest positive rate of LUAD was CEA and the highest positive rates of SCLC were ProGRP and NSE. In terms of single tumor marker detection, CYFRA21-1 possessed the best diagnostic efficiency for LSCC, CEA possessed the best diagnostic efficiency for LUAD, NSE and ProGRP possessed the best diagnostic efficiency for SCLC, respectively. Conclusion: The individual determination of CYFRA21-1, ProGRP, CEA, and NSE has certain clinical application value for the pathological classification of LC.
Keywords: Lung cancer, tumor markers, diagnosis.
Full-Text [PDF 786 kb]   (8 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print



Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Back to the articles list Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 50 queries by YEKTAWEB 4652