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Dosimetric evaluation of a hybrid treatment planning for whole-brain radiation with hippocampal sparing
E.A. Martín-Tovar , A.H. Badillo-Alvarado , L.E. Cocom-Poot , J.L. Gaxiola-Sosa
División de Oncología y Uronefrología, Departamento de Radioterapia, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional “Ignacio García Téllez”, Instituto Mexicano del Seguro Social, CP 97150, Mérida Yucatán, México , enrique.martin.tovar@gmail.com
Abstract:   (43 Views)
Background: To study the possible dosimetric benefits of a Hybrid planning technique that consists of combining intensity modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) for whole brain radiation therapy hippocampal-sparing (WBRT-HS). Materials and Methods: Three types of plans were made for 15 patients, namely Hybrid, pure IMRT, and pure VMAT and retrospectively compared. Each plan was made using contoured structures on computed tomographic (CT) images fused with magnetic resonance imaging (MRI). The homogeneity (HI) and conformity (CI) indices of the planning target volumes (PTVs) were calculated to establish the dosimetric quality in all plans. The dose received to organs at risk (OARs), number of monitor units (MUs) and treatment time were evaluated for each type of planning technique. Results: Hybrid plans showed superior homogeneity (p = 0.04) and conformity (p = 0.01) indices compared to IMRT and VMAT plans. In terms of hippocampus sparing, the Hybrid technique showed almost equal D100% and maximum dose (Dmax) values compared to the other techniques, but without statistical significance (p> 0.05); however, there was a significant difference for the left hippocampus, where the IMRT technique obtained the best result (p <0.001). Hybrid plan values for dose delivered to the remaining OARs, MUs and treatment times were intermediate between those of IMRT and VMAT. Conclusion: Compared to the IMRT and VMAT plans, the hybrid plan showed improved dosimetric plan quality along with intermediate dose values to the OARs.
Keywords: Brain neoplasms, hippocampus, radiotherapy, intensity-modulated.
Full-Text [PDF 719 kb]   (8 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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International Journal of Radiation Research
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