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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 361-366 Back to browse issues page
MiR-144-3p regulates invasion and proliferation activity in hepatocellular carcinoma by targeting SLITRK4
D.B. Xiao , H. Xu , J.C. Li , K.K. Peng , X.L. Jiang , D.X. Wang , F.F. Zhu
Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital of University of South China, Hengyang City, Hunan Province, 421001, China , zff200078@163.com
Abstract:   (326 Views)
Background: miR-144-3p exerts inhibitory roles in hepatocellular carcinoma (HCC). This paper aims to explore that miR-144-3p and its predictive target gene, SLIT- and NTRK-like family member 4 (SLITRK4), in HCC progression. Materials and Methods: The levels of SLITRK4 and miR-144-3p were determined by western blot and qPCR. A loss- and gain-of-function test was used to test whether the relationship between miR-144-3p and SlitrK4 affected the growth of HCC cells. StarBase examined the miR-144-3p target prediction using SLITRK4. Through the use of a luciferase reporter experiment, miR-144-3p's targeting SLITRK4 was identified. The salvage experiment confirmed that miR-144-3p interacts SLITRK4 to regulate the progression of HCC. Results: Findings showned that the expression of miR-144-3p decreased in HCC tissue and cells. MiR-144-3p inhibits deterioration progression of HCC cell progression. MiR-144-3p targeted SLITRK4 and negatively modulated SLITRK4 levels. Besides, miR-144-3p upregulation decreased HCC migration and invasion activity, while SLITRK4 overexpression reduced this inhibition effects. Conclusions: MiR-144-3p regulates invasion and proliferation activity in HCC by targeting SLITRK4. MiR-144-3P/ SLITRK4 axis might provide a potential anti-cancer therapy pathway for clinical diagnosis, treatment and prognosis in hepatoma.
Keywords: MiR-144-3p, SLITRK4, tumor progression, Hepatocellular carcinoma.
Full-Text [PDF 1227 kb]   (60 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Xiao D, Xu H, Li J, Peng K, Jiang X, Wang D et al . MiR-144-3p regulates invasion and proliferation activity in hepatocellular carcinoma by targeting SLITRK4. Int J Radiat Res 2024; 22 (2) :361-366
URL: http://ijrr.com/article-1-5431-en.html

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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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