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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 373-379 Back to browse issues page
Efficacy of radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombosis
Q. Tian , L. Li , F. Zhang , X. Wu
Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. , wywx7606@163.com
Abstract:   (138 Views)
Background: The To investigate the feasibility, efficacy, and toxicity of three-dimensional conformal radiotherapy (3D-CRT) for treatment of patients with advanced hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombosis (PVTT) and/or inferior vena cava tumor thrombosis (IVCTT). Materials and Methods: 53 HCC patients with PVTT/IVCTT undergoing 3D-CRT during the period from September 2008 to January 2014 were analyzed. The Kaplan-Meier method was used to analyze between-group differences in patient baseline information. Univariate and multivariate cox regression analyses were used to identify factors affecting survival in patients with HCC. Results: Computed tomography (CT) scan or MRI (Magnetic Resonance Imaging) of the upper abdomen one month post-radiotherapy showed an overall response rate (CR + PR) of 56.6% (30/53). Univariate analysis revealed that treatment regimen (P = 0.008), alpha fetoprotein (AFP) level (P = 0.012), response to radiotherapy, metastasis to celiac lymph nodes and site of tumor thrombosis were strongly associated with the prognosis of HCC patients with PVTT (P = 0.000). The median survival time was 9 months (95% CI: 7.43-10.57 months) in 23 (43.4%) PVTT patients, and 24 months (95% CI: 20.04-27.96 months) in 30 (56.6%) IVCTT patients. Multivariate Cox regression analysis revealed that metastasis to celiac lymph nodes (P = 0.004) and response to radiotherapy (P = 0.001) were independent factors affecting patients’ survival. Conclusion: 3D-CRT has high efficacy for treating HCC patients with PVTT, and metastasis to celiac lymph nodes and response to radiotherapy are primary factors affecting HCC patients’ survival.
Keywords: Hepatocellular carcinoma, Portal vein tumor thrombosis, Inferior vena cava, Three-dimensional conformal radiotherapy, Clinical efficacy.
Full-Text [PDF 702 kb]   (23 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Tian Q, Li L, Zhang F, Wu X. Efficacy of radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombosis. Int J Radiat Res 2024; 22 (2) :373-379
URL: http://ijrr.com/article-1-5443-en.html

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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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