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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 437-447 Back to browse issues page
Exosome-delivered miRNA-339 represses the progression of gastric cancer via targeting ZNF689 before chemoradiotherapy
L. Liang , Z. Zhang , Z. Cheng , H. Li , H. Jiang
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China , jianghouxiang2023@163.com
Abstract:   (68 Views)
Background: MicroRNAs (miRNAs) have crucial roles in human cancers. Many studies have certified that miRNAs are implicated in tumor progression via exosomes. Nevertheless, whether miRNA-339 is derived by exosomes and its effects in gastric cancer (GC) presents obscure. Therefore, our study attempted to clarify the functional role and molecular mechanism of miRNA-339 in GC. Materials and Methods: In this research, the potential of miRNA-339 in GC was verified through miRNA-339 elevation with cell function assays. Bioinformatics analysis together with mechanical assay was implemented for assessing the regulatory relation between miRNA-339 and zinc finger protein 689 (ZNF689). Moreover, the existence of exosomes was determined via transmission electron microscopy together with nanoparticle tracking analysis. Results: miRNA-339 presented significant down-regulation in GC. miRNA-339 elevation suppressed GC cell proliferation, invasion along with migration while elevated GC cell apoptosis. miRNA-339 targeted ZNF689 3’UTR to repress ZNF689 expression, thereby hindering GC progression. Finally, miRNA-339 was majorly incorporated into exosomes to hinder GC progression. Conclusion: In summary, exosome-delivered miRNA-339 may act to be a tumor repressor in GC by targeting ZNF689, which might be an underlying therapeutic target for GC.
Keywords: Gastric cancer, miRNA-339, ZNF689, exosome.
Full-Text [PDF 3711 kb]   (40 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Liang L, Zhang Z, Cheng Z, Li H, Jiang H. Exosome-delivered miRNA-339 represses the progression of gastric cancer via targeting ZNF689 before chemoradiotherapy. Int J Radiat Res 2024; 22 (2) :437-447
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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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