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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 457-465 Back to browse issues page
The role of m6A-related lncRNAs on prognosis and chemoradiothrapy response of osteosarcoma: potential molecular pathways
Y. Zhou , Y. Bi , M. Wan , N. Xu , Y. Xu , P. Liu , H. Jiang , H. Fang , H. Hu , S. Xu , S. Lan
Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China , xusuyang
Abstract:   (58 Views)
Background: Conventional treatments on osteosarcoma (OS) yield limited improvements in metastatic or relapsed cases, necessitating innovative therapeutic strategies. This study's objective is to reveal the role of long non-coding RNAs (lncRNAs) in prognosis and potential molecular pathways of OS. Materials and Methods: This study integrated bioinformatics, statistical analysis, and computational techniques to investigate m6A-related prognostic lncRNA clusters in OS. Consensus clustering and risk analysis were performed on the m6A-related prognostic lncRNAs. Nomogram model was built for survival prediction, and was assessed using survival time receiver operator characteristic (ROC) analysis and decision curves. A competitive endogenous RNA (ceRNA) network was built to explore lncRNA-miRNA (microRNA)-mRNA interactions using the microRNA database and metascape website, followed by functional enrichment analyses. Results: The analysis unveiled three distinct OS clusters, with Cluster 2 exhibiting the highest risk in the immune microenvironment. High risk 7-lncRNA signature demonstrated strong prognostic value in predicting OS overall survival. The ceRNA network highlighted complex interactions among mRNAs, miRNAs and lncRNAs. Functional enrichment analysis indicated that mRNAs within the ceRNA network were linked to many biological functions. Furthermore, 30 differentially expressed genes (DEGs) derived from low-risk and high-risk groups enriched in GO-BP connected to MAGE (melanoma antigen gene) family member A2 (MAGEA2) and MAGEA2B. These DEGs in high risk group were also upregulated in the three KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway. Conclusion: This study disclosed the role of high-risk m6A-associated lncRNAs in prognosis and potential molecular pathways of OS. These findings provided novel insights into OS pathogenesis and potential therapeutic targets, warranting further validation in clinical settings.
Keywords: osteosarcoma, long non-coding RNA (lncRNA), m6A modification, prognosis, chemoradiotherapy response, ceRNA network.
Full-Text [PDF 2398 kb]   (15 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Zhou Y, Bi Y, Wan M, Xu N, Xu Y, Liu P, et al . The role of m6A-related lncRNAs on prognosis and chemoradiothrapy response of osteosarcoma: potential molecular pathways. Int J Radiat Res 2024; 22 (2) :457-465
URL: http://ijrr.com/article-1-5469-en.html

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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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