[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
About the Journal
Editorial Board
Keywords
For Authors::
Aims and Scope
Call for Papers
Submission Instructions
For Reviewers::
Referee page
Subscription::
Subscription Form
News & Events::
Journal News
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE
:: Volume 22, Issue 3 (7-2024) ::
Int J Radiat Res 2024, 22(3): 657-662 Back to browse issues page
Correlation between perivascular adipose tissue surrounding coronary arteries measured on coronary artery CT Angiography and the presence and severity of CAD
S.S. Yuan , Q. Yuan , F.Y. Xing , Y.Q. Wang
Department of Radiology, Shangyu People's Hospital of Shaoxing, Shaoxing, Zhejiang 312300, China
Abstract:   (864 Views)
Background: The aim of this study was to explore the relationship between peri-coronary adipose tissue volume (V-PCAT), as assessed via coronary artery CT angiography (CCTA), and the presence and severity of coronary artery disease (CAD). Materials and Methods: A retrospective analysis was conducted on 160 individuals with suspected CAD who underwent CCTA from June 2020 to December 2021. Quantification of both epicardial adipose tissue volume (V-EAT) and V-PCAT was performed. Clinical data, lipid metrics, and differences in adipose tissue volume between CAD and non-CAD groups were assessed. Variables influencing CAD were analyzed using univariate and multivariate logistic regression. The diagnostic accuracy of adipose tissue volume in predicting CAD was determined through receiver operating characteristic curves. The association between adipose tissue volume and coronary artery stenosis severity was investigated. Results: The analysis included 100 patients with CAD and 60 without CAD. V-EAT and V-PCAT were notably higher in the CAD group than the without CAD group. After adjustments for confounding factors, V-EAT and V-PCAT showed a positive association with CAD. The area under the curve of V-PCAT was 0.875. Conclusions: V-PCAT, measured via CCTA was substantial associated with CAD while serving as an independent risk determinant. Additionally,   V-PCAT, notably correlated with the severity of coronary artery stenosis.
Keywords: Coronary artery perivascular adipose tissue volume, Coronary artery CT angiography, CAD, Coronary artery stenosis.
Full-Text [PDF 768 kb]   (222 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Benjamin EJ, Virani SS and Callaway CW, et al (2018) Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association. Circulation, 137(12): e67-e492. [DOI:10.1161/CIR.0000000000000558]
2. (2017) Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390(10100): 1151-1210.
3. Gaudino M, Andreotti F and Kimura T (2023) Current concepts in coronary artery revascularisation. Lancet, 401(10388): 1611-1628. [DOI:10.1016/S0140-6736(23)00459-2]
4. Sharma A and Arbab-Zadeh A (2012) Assessment of coronary heart disease by CT angiography: current and evolving applications. Journal of Nuclear Cardiology, 19(4): 796-806. [DOI:10.1007/s12350-012-9556-3]
5. Abdelrahman KM, Chen MY and Dey AK, et al (2020) Coronary Computed Tomography Angiography from Clinical Uses to Emerging Technologies: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 76(10): 1226-1243. [DOI:10.1016/j.jacc.2020.06.076]
6. Williams MC, Reid JH and McKillop G, et al (2011) Cardiac and coronary CT comprehensive imaging approach in the assessment of coronary heart disease. Heart, 97(15): 1198-1205. [DOI:10.1136/heartjnl-2011-300037]
7. Brandt V, Decker J and Schoepf UJ, et al (2022) Additive value of epicardial adipose tissue quantification to coronary CT angiography-derived plaque characterization and CT fractional flow reserve for the prediction of lesion-specific ischemia. European Radiology, 32(6): 4243-4252. [DOI:10.1007/s00330-021-08481-w]
8. Liu Z, Wang S and Wang Y, et al (2019) Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease. Atherosclerosis, 284: 230-236. [DOI:10.1016/j.atherosclerosis.2019.01.033]
9. Guglielmo M, Lin A and Dey D, et al (2021) Epicardial fat and coronary artery disease: Role of cardiac imaging. Atherosclerosis, 321:30-38. [DOI:10.1016/j.atherosclerosis.2021.02.008]
10. Kim SH, Chung JH, Kwon BJ, Song SW and Choi WS (2014) The associations of epicardial adipose tissue with coronary artery disease and coronary atherosclerosis. International Heart Journal, 55(3): 197-203. [DOI:10.1536/ihj.13-303]
11. Shan D, Dou G and Yang J, et al (2021) Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients. Oxidative Medicine and Cellular Longevity, 2021: 6663948. [DOI:10.1155/2021/6663948]
12. Salazar J, Luzardo E and Mejias JC, et al (2016) Epicardial Fat: Physiological, Pathological, and Therapeutic Implications. Cardiology Research and Practice, 2016(1291537). [DOI:10.1155/2016/1291537]
13. Vyas V, Hunter RJ, Longhi MP and Finlay MC (2020) Inflammation and adiposity: new frontiers in atrial fibrillation. Europace, 22(11): 1609-1618. [DOI:10.1093/europace/euaa214]
14. Niemann M, Alkadhi H, Gotschy A, Kozerke S and Manka R (2015) [Epicardial fat: Imaging and implications for diseases of the cardiovascular system]. Herz, 40 Suppl 3: 282-290. [DOI:10.1007/s00059-014-4146-6]
15. Patel VB, Shah S, Verma S and Oudit GY (2017) Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease. Heart Failure Reviews, 22(6): 889-902. [DOI:10.1007/s10741-017-9644-1]
16. Archer JM, Raggi P, Amin SB, Zhang C, Gadiyaram V and Stillman AE (2021) Season and clinical factors influence epicardial adipose tissue attenuation measurement on computed tomography and may hamper its utilization as a risk marker. Atherosclerosis, 321: 8-13. [DOI:10.1016/j.atherosclerosis.2021.01.025]
17. Packer M (2018) Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium. Journal of the American College of Cardiology, 71(20): 2360-2372. [DOI:10.1016/j.jacc.2018.03.509]
18. Mehta R, Bello-Chavolla OY and Mancillas-Adame L, et al (2022) Epicardial adipose tissue thickness is associated with increased COVID-19 severity and mortality. International Journal of Obesity, 46(4): 866-873. [DOI:10.1038/s41366-021-01050-7]
19. Colonetti T, Grande AJ and Amaral MC, et al (2021) Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses. Heart Failure Reviews, 26(6): 1399-1411. [DOI:10.1007/s10741-020-09965-5]
20. Ma R, Fari R and van der Harst P, et al (2023) Evaluation of pericoronary adipose tissue attenuation on CT. British Journal of Radiology, 96(1145): 20220885. [DOI:10.1259/bjr.20220885]
21. Mazurek T and Opolski G (2015) Pericoronary adipose tissue: a novel therapeutic target in obesity-related coronary atherosclerosis. Journal of the American College of Nutrition, 34(3): 244-254. [DOI:10.1080/07315724.2014.933685]
22. Yuvaraj J, Lin A and Nerlekar N, et al (2021) Pericoronary Adipose Tissue Attenuation Is Associated with High-Risk Plaque and Subsequent Acute Coronary Syndrome in Patients with Stable Coronary Artery Disease. Cells, 10(5): 1143. [DOI:10.3390/cells10051143]
23. Hoshino M, Yang S and Sugiyama T, et al (2020) Peri-coronary inflammation is associated with findings on coronary computed tomography angiography and fractional flow reserve. Journal of Cardiovascular Computed Tomography, 14(6): 483-489. [DOI:10.1016/j.jcct.2020.02.002]
24. Chen X, Dang Y and Hu H, et al (2021) Pericoronary adipose tissue attenuation assessed by dual-layer spectral detector computed tomography is a sensitive imaging marker of high-risk plaques. Quantitative Imaging in Medicine and Surgery, 11(5): 2093-2103. [DOI:10.21037/qims-20-860]
25. Shi KL, Qi L and Mao DB, et al (2015) Impact of age on epicardial and pericoronary adipose tissue volume. European Review for Medical and Pharmacological Sciences, 19(17): 3257-3265.
26. Gensini GG (1983) A more meaningful scoring system for determining the severity of coronary heart disease. American Journal of Cardiology, 51(3): 606. [DOI:10.1016/S0002-9149(83)80105-2]
27. Cabrera-Rego JO, Iacobellis G and Castillo-Herrera JA, et al (2014) Epicardial fat thickness correlates with carotid intima-media thickness, arterial stiffness, and cardiac geometry in children and adolescents. Pediatric Cardiology, 35(3): 450-456. [DOI:10.1007/s00246-013-0799-9]
28. Fitzgibbons TP and Czech MP (2014) Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. Journal of the American Heart Association, 3(2): e000582. [DOI:10.1161/JAHA.113.000582]
29. Greenstein AS, Khavandi K and Withers SB, et al (2009) Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation, 119(12): 1661-1670. [DOI:10.1161/CIRCULATIONAHA.108.821181]
30. Mahabadi AA, Massaro JM and Rosito GA, et al (2009) Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: The Framingham Heart Study. European Heart Journal, 30(7): 850-856. [DOI:10.1093/eurheartj/ehn573]
31. Sarin S, Wenger C and Marwaha A, et al (2008) Clinical significance of epicardial fat measured using cardiac multislice computed tomography. American Journal of Cardiology, 102(6): 767-771. [DOI:10.1016/j.amjcard.2008.04.058]
32. Mahabadi AA, Berg MH and Lehmann N, et al (2013) Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: The Heinz Nixdorf Recall Study. Journal of the American College of Cardiology, 61(13): 1388-1395. [DOI:10.1016/j.jacc.2012.11.062]
33. Hassan M, Said K, Rizk H, et al (2016). Segmental peri-coronary epicardial adipose tissue volume and coronary plaque characteristics. European heart journal. Cardiovascular Imaging, 17: 1169-1177. [DOI:10.1093/ehjci/jev298]
34. de Vos AM, Prokop M and Roos CJ, et al (2008) Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. European Heart Journal, 29(6): 777-783. [DOI:10.1093/eurheartj/ehm564]
35. Balcer B, Dykun I, Schlosser T, Forsting M, Rassaf T and Mahabadi AA (2018) Pericoronary fat volume but not attenuation differentiates culprit lesions in patients with myocardial infarction. Atherosclerosis, 276: 182-188. [DOI:10.1016/j.atherosclerosis.2018.05.035]
Add your comments about this article
Your username or Email:

CAPTCHA

XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Yuan S, Yuan Q, Xing F, Wang Y. Correlation between perivascular adipose tissue surrounding coronary arteries measured on coronary artery CT Angiography and the presence and severity of CAD. Int J Radiat Res 2024; 22 (3) :657-662
URL: http://ijrr.com/article-1-5615-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 3 (7-2024) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.07 seconds with 50 queries by YEKTAWEB 4713