Department of Functional Neurology, Wuxi People's Hospital, Wuxi, Jiangsu, China , kkrr83@163.com
Abstract: (367 Views)
Background:To assess the value of color Doppler ultrasonography (CDUS) in diagnosing carotid atherosclerotic plaque (CAP) in cerebral infarction (CI) patients. Materials and Methods: Totally 100 CI patients in our hospital from March 2021 to March 2023 were included in the study group (SG), and another 98 patients who received physical examination at the same time were included in the control group (CG). CDUS was performed to determine the type, distribution and total detection rate of carotid atherosclerotic plaque, and to evaluate carotid blood flow parameters, carotid intima-media thickness (IMT) and stenosis degree in the two groups. Results: No significant difference of plaque in the proportion of external carotid artery (ECA), internal carotid artery (ICA), common carotid artery (CCA) and carotid artery bifurcation between the two groups (P>0.05). Relative to the CG, the detection rate of each type of carotid atherosclerotic plaque in the SG was significantly higher (P=0.03 and P<0.001), peak systolic flow velocity (PSV), minimum diastolic flow velocity (EDV), and resistance index (RI) of carotid blood flow were lower, and IMT was higher in the SG (P<0.05), and the proportion of mild, moderate and severe carotid artery stenosis in the SG were higher (P<0.01 and P<0.001). Conclusion: CDUS can detect the distribution and quantity of plaques, determine the type and stability of plaques, and assess the carotid blood flow parameters and stenosis, which is valuable for the diagnosis of CAP in CI, and guides the formulation of clinical treatment plan.
1. 1. Zhao, Y, Zhang X, Chen X, et al. (2022) Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment. Int J Mol Med, 49(2). [DOI:10.3892/ijmm.2021.5070]
2. Saia V and Pantoni L (2009) Progressive stroke in pontine infarction. Acta Neurol Scand, 120(4): 213-5. [DOI:10.1111/j.1600-0404.2009.01161.x]
3. Takase KI (2020) Cardiogenic cerebral infarction in the parietal lobe predicts the development of post-stroke epilepsy. Seizure, 80: 196-200. [DOI:10.1016/j.seizure.2020.06.018]
4. Vergallo R and Crea F (2020) Atherosclerotic plaque healing. N Engl J Med, 383(9): 846-857. [DOI:10.1056/NEJMra2000317]
5. Xu M, He XY, Huang P (2020) The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction. Biomed Res Int, 2020: 6685740. [DOI:10.1155/2020/6685740]
6. Ahmadi A, Argulian E, Leipsic J, et al. (2019) From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events: JACC State-of-the-Art Review. J Am Coll Cardiol, 74(12): 1608-1617. [DOI:10.1016/j.jacc.2019.08.012]
7. Arboix A and Martí-Vilalta JL (2009) Lacunar stroke. Expert Rev Neurother, 9(2): 179-96. [DOI:10.1586/14737175.9.2.179]
8. Ni T, Fu Y, Zhou W, et al. (2020) Carotid plaques and neurological impairment in patients with acute cerebral infarction. PLoS One, 15(1): e0226961. [DOI:10.1371/journal.pone.0226961]
9. Yuan C (2008) Carotid atherosclerosis and magnetic resonance imaging. JACC Cardiovasc Imaging, 1(1): 58-60. [DOI:10.1016/j.jcmg.2007.10.003]
10. Manrique-Zegarra M, García-Pastor A, Castro-Reyes E, et al. (2022) CT angiography for diagnosis of carotid near-occlusion: a digital subtraction angiography validation study. Neuroradiology, 64(9): 1729-1735. [DOI:10.1007/s00234-022-02995-w]
11. Grant EG, Benson CB, Moneta GL, et al. (2003) Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of radiologists in ultrasound consensus conference. Radiology, 229(2): 340-6. [DOI:10.1148/radiol.2292030516]
12. Caiati C, Lepera ME, Pollice P, et al. (2020) A new noninvasive method for assessing mild coronary atherosclerosis: transthoracic convergent color Doppler after heart rate reduction. Validation vs. intracoronary ultrasound. Coron Artery Dis, 31(6): 500-511. [DOI:10.1097/MCA.0000000000000873]
13. Song T and Chen WD (2021) Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway. Bioengineered, 12(1): 8135-8146. [DOI:10.1080/21655979.2021.1987130]
14. Jiang C, Zhang J, Zhu J, et al. (2021) Association between coexisting intracranial artery and extracranial carotid artery atherosclerotic diseases and ipsilateral cerebral infarction: a Chinese Atherosclerosis Risk Evaluation (CARE-II) study. Stroke Vasc Neurol, 6(4): 595-602. [DOI:10.1136/svn-2020-000538]
15. Brinjikji W, Huston J 3rd, Rabinstein AA, et al. (2016) Contemporary carotid imaging: from degree of stenosis to plaque vulnerability. J Neurosurg, 124(1): 27-42. [DOI:10.3171/2015.1.JNS142452]
16. Murray CSG, Nahar T, Kalashyan H, et al. (2018) Ultrasound assessment of carotid arteries: Current concepts, methodologies, diagnostic criteria, and technological advancements. Echocardiography, 35(12): 2079-2091. [DOI:10.1111/echo.14197]
17. Jiang L and Zhao Y (2017) The value of color Doppler ultrasound in the diagnosis of lower extremity vascular disease in type 2 diabetes and an analysis of related factors. Minerva Endocrinol, 42(3): 223-227. [DOI:10.23736/S0391-1977.16.02352-X]
18. Chen L, Yang Q, Ding R, et al. (2018) Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP-2 and MMP-9 were associated with acute cerebral infarction. Exp Ther Med, 16(6): 5253-5257. [DOI:10.3892/etm.2018.6868]
19. Wang J, Wang L, Shen Y, et al. (2022) Relationship between carotid artery angle and plaque morphology in acute cerebral infarction patients. Neurologist, 27(5): 240-244. [DOI:10.1097/NRL.0000000000000410]
20. Macharzina RR, Kocher S, Messé SR, et al. (2018) 4-Dimensionally guided 3-dimensional color-Doppler ultrasonography quantifies carotid artery stenosis with high reproducibility and accuracy. JACC Cardiovasc Imaging, 11(3): 386-396. [DOI:10.1016/j.jcmg.2017.02.018]
Guo L, Guo X, Kong R. Value of color Doppler ultrasonography in diagnosis of carotid atherosclerotic plaque in cerebral infarction patients. Int J Radiat Res 2025; 23 (1) :245-248 URL: http://ijrr.com/article-1-6110-en.html