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Hepatoprotective efficacy of Grewia asiatica fruit against oxidative stress in swiss albino mice
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| K.V. Sharma, R. Sisodia |
| , sharma.krishna.v@gmail.com |
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Abstract: (14688 Views) |
| Background: The radioprotective effect of Grewia
asiatica fruit (GAE) which contains anthocyanin type
cyanidin 3- glucoside, vitamin C, A, minerals,
carotenes and dietary fibers etc was studied.
Materials and Methods: For study Swiss albino mice
were divided into five groups-1. Control (vehicle
treated) 2. GAE treated (700 mg / Kg. b.wt / day for
fifteen days), 3. Irradiated (5 Gy), 4. GAE + Irradiated
and 5. Irradiated + GAE treated. Results: The
irradiation of animals resulted in a significant
depletion in the DNA and RNA level at all intervals
studied viz 1-30 days in comparison to control group.
Treatment of mice with GAE before and after
irradiation caused a significant elevation in liver DNA
and RNA level in comparison to irradiated mice.
Photomicrograph of liver histology also showed that
pre and post supplementation of GAE provides
protection against radiation. Similarly counting of
different type hepatocytes also showed that GAE
protect the liver against radiation. Conclusion: Thus
biochemical and histopathological results proves that
GAE has the potential against radiation. Iran. J.
Radiat. Res., 2010 8 (2): 75-85 |
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| Keywords: Radioprotection, mice liver, DNA, RNA, liver histology, hepatocyte count. |
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Full-Text [PDF 878 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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