|
Impact of Slice Thickness and Grid Size on Dose Calculation in Intensity Modulated and Volumetric-Modulated Arc Radiotherapy in Head and Neck Cancer
|
N. Ayman   , A. Abdelaal , H.H. Amer , H.S. Mohammed |
| Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt , haitham@sci.cu.edu.eg |
|
|
Abstract: (661 Views) |
Background: The grid size in radiotherapy can have an impact on dose values. When calculating the dose, slice width is a crucial component to consider. A thinner slice provides for a more precise mean dose estimate than a thicker slice. Materials and Methods: For this study, 35 patients with Head and Neck (H&N) cancer were chosen. Planning Target Volume (PTV) and Organ At Risks (OARs) were optimized using the same criteria. Intensity Modulated Radiation Therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans, which were designed with slice thicknesses (3,5,7 mm) and grid sizes (2,3,5, 7 and 8 mm). Homogeneity (HI) and Conformity Index (CI), dose points, such as D2%, D50%, and D98% for each OAR, assessed in relation to slice thickness and grid size. Results: There is a substantial difference (p<0.05) between grid sizes 3mm, 5mm, 7mm, and 8mm in IMRT and VMAT, but no significant difference (p>0.05) in target and OAR dose between grid sizes 2mm and 3mm. Conversely, the target dosage and OAR dose are significantly affected by variations in the Computed Tomography (CT) slice thickness, with a significant difference (p<0.05) seen in the target dose between 3mm, 5mm, and 7mm slice thickness and an insignificant difference (p>0.05) between 5mm and 7mm in OAR dose. Conclusions: According to this study, using the grid size of 2 mm is not recommended because it generates memory issues in the treatment planning system (TPS) and takes a lot of time, neither of which have a practical clinical effect. |
|
| Keywords: Radiotherapy, intensity modulated, radiotherapy planning, radiotherapy dosage, computer-assisted tomography. |
|
|
Full-Text [PDF 989 kb]
(279 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| References |
1. D'Agostino E, Bogaerts R, Defraene G, de Freitas Nascimento L, Van den Heuvel F, Verellen D, et al. (2013) Peripheral doses in radiotherapy: A comparison between IMRT, VMAT and tomotherapy. Radiation Measurements, 57: 62-67. [ DOI:10.1016/j.radmeas.2013.04.016] 2. Huang K, Rhee DJ, Ger R, Layman R, Yang J, Cardenas CE, et al. (2021) Impact of slice thickness, pixel size, and CT dose on the performance of automatic contouring algorithms. J Appl Clin Med Phys, 22(5): 168-174. [ DOI:10.1002/acm2.13207] 3. Alirezaei Z, Amouheidari AR, Abedi I, Davanian F, Shokrani P, Nazemzadeh MR (2021) Optimization of CT slice thickness in 3D-CRT and IMRT planning of low grade glioma. International Journal of Radiation Research, 19(2): 291-298. [ DOI:10.52547/ijrr.19.2.6] 4. Marta GN, Silva V, de Andrade Carvalho H, de Arruda FF, Hanna SA, Gadia R, et al. (2014) Intensity-modulated radiation therapy for head and neck cancer: systematic review and meta-analysis. Radiotherapy and Oncology, 110(1): 9-15. [ DOI:10.1016/j.radonc.2013.11.010] 5. Holt A, Van Gestel D, Arends MP, Korevaar EW, Schuring D, Kunze-Busch MC, et al. (2013) Multi-institutional comparison of volumetric modulated arc therapy vs. intensity-modulated radiation therapy for head-and-neck cancer: a planning study. Radiation Oncology, 8(1): 1-11. [ DOI:10.1186/1748-717X-8-26] 6. Yip C, Thomas C, Michaelidou A, James D, Lynn R, Lei M, et al. (2014) Co-registration of cone beam CT and planning CT in head and neck IMRT dose estimation: a feasible adaptive radiotherapy strategy. The British Journal of Radiology, 87(1034): 20130532. [ DOI:10.1259/bjr.20130532] 7. Partridge M, Trapp JV, Adams EJ, Leach MO, Webb S, Seco J (2006) An investigation of dose calculation accuracy in intensity-modulated radiotherapy of sites in the head & neck. Physica Medica, 22(3): 97-104. [ DOI:10.1016/S1120-1797(06)80003-7] 8. Wiezorek T, Brachwitz T, Georg D, Blank E, Fotina I, Habl G, et al. (2011) Rotational IMRT techniques compared to fixed gantry IMRT and tomotherapy: multi-institutional planning study for head-and-neck cases. Radiation Oncology, 6(1): 1-10. [ DOI:10.1186/1748-717X-6-20] 9. Zhao N, Yang R, Jiang Y, Tian S, Guo F, Wang J (2015) A hybrid IMRT/VMAT technique for the treatment of nasopharyngeal cancer. BioMed Research International, 2015: 940102. [ DOI:10.1155/2015/940102] 10. Bhide SA and Nutting CM (2010) Advances in radiotherapy for head and neck cancer. Oral Oncology, 46(6): 439-441. [ DOI:10.1016/j.oraloncology.2010.03.005] 11. Moreno AC, Frank SJ, Garden AS, Rosenthal DI, Fuller CD, Gunn GB, et al. (2019). Intensity modulated proton therapy (IMPT)-The future of IMRT for head and neck cancer. Oral Oncology, 88: 66-74. [ DOI:10.1016/j.oraloncology.2018.11.015] 12. Chen J, Mok E, Wang L, Chen C, Le QT (2013) Volumetric-modulated arc radiotherapy for skull-base and non-skull-base head and neck Cancer: a treatment planning comparison with fixed beam IMRT. Technology in Cancer Research & Treatment, 12(1): 11-18. [ DOI:10.7785/tcrt.2012.500251] 13. Didona A, Lancellotta V, Zucchetti C, Panizza BM, Frattegiani A, Iacco M, et al. (2018) Is volumetric modulated arc therapy with constant dose rate a valid option in radiation therapy for head and neck cancer patients?. Reports of Practical Oncology and Radiotherapy, 23(3): 175-182. [ DOI:10.1016/j.rpor.2018.02.007] 14. Ali YH, El Shahat K, Abou Zeid H, Ashry HA (2017) A comparison of the gamma index and dose volume histogram of patient for IMRT/VMAT with different QA systems. Journal of Scientific Research in Science, 34(part1): 313-332. [ DOI:10.21608/jsrs.2018.14054] 15. Ali A, Hussein A, Galal M, El Shahat K (2022) Effect of calculation grid size on plan calculation for anisotropic analytical algorithm and Acuros XB Algorithm in lung stereotactic body radiotherapy. Journal of Radiation and Nuclear Applications, 7(3): 1-5. [ DOI:10.18576/jrna/070301] 16. Esmailzadeh A, Abedi I, Khorasani A (2023) Investigating variation of dose gradient index by different grid sizes in intensity-modulated radiation therapy of optic nerve sheath meningioma. Applied Radiation and Isotopes, 193: 110657. [ DOI:10.1016/j.apradiso.2023.110657] 17. Grégoire V and Mackie TR (2011) State of the art on dose prescription, reporting and recording in intensity-modulated radiation therapy (ICRU report No. 83). Cancer/Radiothérapie, 15(6-7): 555-559. [ DOI:10.1016/j.canrad.2011.04.003] 18. Srivastava SP, Cheng CW, Das IJ (2017) The dosimetric and radiobiological impact of calculation grid size on head and neck IMRT. Practical Radiation Oncology, 7(3): 209-217. [ DOI:10.1016/j.prro.2016.10.001] 19. Park JM, Park S-Y, Kim J-i, Carlson J, Kim JH (2017) The influence of the dose calculation resolution of VMAT plans on the calculated dose for eye lens and optic pathway. Australasian Physical & Engineering Sciences in Medicine, 40(1): 209-17. [ DOI:10.1007/s13246-016-0517-z] 20. Prabhakar R, Ganesh T, Rath GK, Julka PK, Sridhar PS, Joshi RC, Thulkar S (2009) Impact of different CT slice thickness on clinical target volume for 3D conformal radiation therapy. Medical Dosimetry, 34(1): 36-41. [ DOI:10.1016/j.meddos.2007.09.002] 21. Feygelman V, Zhang G, Stevens C (2010) Initial dosimetric evaluation of SmartArc-a novel VMAT treatment planning module implemented in a multi‐vendor delivery chain. Journal of Applied Clinical Medical Physics, 11(1): 99-116. [ DOI:10.1120/jacmp.v11i1.3169] 22. Caivano R, Fiorentino A, Pedicini P, Califano G, Fusco V (2014) The impact of computed tomography slice thickness on the assessment of stereotactic, 3D conformal and intensity-modulated radiotherapy of brain tumors. Clinical and Translational Oncology, 16: 503-508. [ DOI:10.1007/s12094-013-1111-4] 23. Niemierko A and Goitein M (1989). The influence of the size of the grid used for dose calculation on the accuracy of dose estimation. Medical Physics, 16(2): 239-247. [ DOI:10.1118/1.596419] 24. Chun M, Kim JI, Oh DH, Wu HG, Park JM (2020) Effect of dose grid resolution on the results of patientspecific quality assurance for intensity-modulated radiation therapy and volumetric modulated arc therapy. International Journal of Radiation Research, 18(3): 521-530.
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Ayman N, Abdelaal A, Amer H, Mohammed H. Impact of Slice Thickness and Grid Size on Dose Calculation in Intensity Modulated and Volumetric-Modulated Arc Radiotherapy in Head and Neck Cancer. Int J Radiat Res 2025; 23 (2) :263-270 URL: http://ijrr.com/article-1-6222-en.html
|
