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Investigation of radioprotective effects of WR-1065 and acetylsalicylic acid by micronucleus assay
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A. Yalcin   , K. Tabakcioglu , V.Y. Caloglu , C. Uzal , I.K. Omurlu |
| Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey , aydoganyalcin@gmail.com |
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Abstract: (35 Views) |
Background: The current study aimed to investigate the ability of acetylsalicylic acid (ASA) to prevent ionizing radiation-induced DNA damage in human lymphocytes via the micronucleus (MN) assay and compare it with the efficacy of the agent WR-1065 (2-[(3-Aminopropyl) amino] ethanethiol dihydrochloride), which exhibits radioprotective activity. Materials and Methods: Peripheral blood samples were obtained from four participants, and nine experimental groups were established. Blood samples were treated with 25 µg/mL ASA and 40 µg/mL WR-1065 for 30 min before irradiation. After treatment, the samples were irradiated with 6 MV X-rays in the linear accelerator (LINAC) unit at doses of 2 Gy and 4 Gy. All blood samples were then cultured for the micronucleus assay. Results: In vitro treatments with ASA and WR-1065 at the indicated doses did not result in statistically significant changes in MN frequencies (p˃0.05). Conclusion: Both drugs were did not exhibit radioprotective effects in the experimental model used. |
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| Keywords: Acetylsalicylic acid, WR-1065, micronucleus, radioprotection, ionizing radiation |
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Full-Text [PDF 709 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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