Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey , aydoganyalcin@gmail.com
Abstract: (35 Views)
Background:The current study aimed to investigate the ability of acetylsalicylic acid (ASA) to prevent ionizing radiation-induced DNA damage in human lymphocytes via the micronucleus (MN) assay and compare it with the efficacy of the agent WR-1065 (2-[(3-Aminopropyl) amino] ethanethiol dihydrochloride), which exhibits radioprotective activity. Materials and Methods: Peripheral blood samples were obtained from four participants, and nine experimental groups were established. Blood samples were treated with 25 µg/mL ASA and 40 µg/mL WR-1065 for 30 min before irradiation. After treatment, the samples were irradiated with 6 MV X-rays in the linear accelerator (LINAC) unit at doses of 2 Gy and 4 Gy. All blood samples were then cultured for the micronucleus assay. Results: In vitro treatments with ASA and WR-1065 at the indicated doses did not result in statistically significant changes in MN frequencies (p˃0.05). Conclusion: Both drugs were did not exhibit radioprotective effects in the experimental model used.