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Diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in malignant biliary obstruction
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Z.P. Koç   , P.P. Özcan , E. Reyhan , M. Yaldız , E. Üçbilek |
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Abstract: (43 Views) |
Background: Our investigation employed a retrospective methodological approach, examining a sample of 45 participants (55.6% male, 44.4% female). The average age was 64 years. All participants presented clinical manifestations suggestive of malignant biliary obstruction. Initial diagnoses were established through advanced imaging techniques, specifically endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP). The study design involved a retrospective analysis of data obtained from the entire cohort to ascertain the diagnostic precision of FDG-PET imaging protocol in this specific clinical context. We also conducted a comparative analysis between the imaging results and the definitive findings from surgical interventions and pathological examinations. To quantitatively assess the diagnostic efficacy of FDG-PET scans, we employed ROC curve analysis as our primary statistical instrument. Results: Imaging studies through FDG-PET scans yielded a sensitivity value at 86.1% with a relatively lower specificity level standing at around 66.7%. These diagnostic parameters underscore the FDG-PET modality's particular strength in precise lesion localization. The imaging technique exhibited marked efficacy in delineating areas of concern, proving especially valuable in guiding targeted diagnostic sampling procedures. Conclusion: Despite exhibiting only moderate specificity, integrating FDG-PET imaging into surgical planning protocols afforded significant alterations in patient treatment plans. The modality’s value manifests in two critical domains: detection and localization of malignant biliary obstructions and informing the subsequent management approach. It represents a valuable diagnostic and prognostic tool in the clinical context. |
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| Keywords: Biliary stasis, 18F-FDG, positron emission tomography. |
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Full-Text [PDF 608 kb]
(15 Downloads)
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Type of Study: Short Report |
Subject:
Radiation Biology
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