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Pyroptosis-related gene signatures in ovarian cancer treatment follow-up using MRI
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W. Chu   , D. Huang |
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Abstract: (12 Views) |
Background: Ovarian cancer remains a significant challenge due to its heterogeneity and variable treatment response. Pyroptosis, an inflammatory form of programmed cell death, may influence tumor progression and treatment outcomes. Dynamic contrast-enhanced MRI (DCE-MRI) is a promising tool for monitoring treatment response in ovarian cancer. This study investigates pyroptosis-related gene (PRG) signatures and their correlation with MRI findings in ovarian cancer treatment follow-up. Materials and Methods: Differentially expressed PRGs (DE-PRGs) were identified from public datasets (e.g., GEO) and intersected with ovarian cancer gene expression data. Core PRGs were selected using LASSO regression, and their expression was correlated with DCE-MRI parameters (tumor perfusion and vascularity). Acetaminophen was evaluated as a potential therapeutic agent, with treatment effects monitored via MRI. Results: Seven core PRGs (e.g., NLRP3, TNFRSF21) were identified, showing significant correlations with tumor vascularity (r=0.71–0.77, p<0.05). DCE-MRI revealed elevated tumor perfusion (0.92±0.15 mL/min/g vs. 0.56±0.12 mL/min/g in controls, p<0.01), strongly associated with NLRP3 and TNFRSF21 expression. Acetaminophen treatment reduced tumor vascularity by 15% (p < 0.05), as observed via DCE-MRI, suggesting a potential therapeutic role. Conclusion: PRG signatures, particularly NLRP3 and TNFRSF21, are promising biomarkers for monitoring ovarian cancer treatment response. DCE-MRI effectively tracks treatment-induced changes in tumor vascularity, supporting its use in follow-up. Acetaminophen’s therapeutic potential requires further validation. Integrating PRG expression with MRI offers a novel approach to personalize ovarian cancer management. |
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| Keywords: Ovarian neoplasms, pyroptosis, magnetic resonance imaging, gene expression profiling, biomarkers. |
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Full-Text [PDF 1373 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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