[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 1 (1-2022) ::
Int J Radiat Res 2022, 20(1): 157-162 Back to browse issues page
Therapeutic mechanism of 32-P application combined with timolol maleate for infantile superficial hemangioma
R.X. Ma, Z.L. Li
Department of Nuclear Medicine, Xingtai People's Hospital, Xingtai, 054001, China , 13730133835@163.com
Abstract:   (742 Views)
Background: This study aims to explore the therapeutic mechanism of 32P application combined with timolol maleate for infantile superficial hemangioma. Materials and Methods: In this study, 60 nude mice were enrolled to establish the transplantation model of infantile hemangioma in nude mice. They were randomly divided into control group, administration group and combined administration group, with 20 mice in each group. The expressions of EGFL7 and VEGF were detected by RT-PCR, and the expressions of renin and ang II were detected by Western blot. Results: After the administration of timolol maleate, the expression of EGFL7, VEGF, renin and Ang  II decreased (P < 0.05). The levels of EGFL7, VEGF, renin and Ang II were further down regulated by combined scheme of 32P application and timolol maleate (P<0.05). Conclusion: 32P application combined with timolol maleate can improve the therapeutic effect of infantile superficial hemangioma by inhibiting the expression of vascular endothelial growth factor, renin and angiotensin II.
 
Keywords: Hemangioma, timolol maleate, 32-P, angiotensin II, vascular endothelial growth factor.
Full-Text [PDF 1642 kb]   (512 Downloads)    
Type of Study: Original Research | Subject: Radiobiology
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ma R, Li Z. Therapeutic mechanism of 32-P application combined with timolol maleate for infantile superficial hemangioma. Int J Radiat Res. 2022; 20 (1) :157-162
URL: http://ijrr.com/article-1-4087-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 1 (1-2022) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4414