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:: Volume 22, Issue 4 (10-2024) ::
Int J Radiat Res 2024, 22(4): 963-970 Back to browse issues page
Long non-coding RNA SSC4D as a potential diagnostic biomarker promotes gastric cell proliferation and metastasis
J. Zhou , T. Jiang , Q. Qi
Department of Pediatric, Haining Traditional Chinese Medicine Hospital, Jiaxing, Zhejiang, 314400, China , qiqingqing2023@163.com
Abstract:   (569 Views)
Background: Scavenger receptor cysteine-rich family member with 4 domains (SSC4D) is aberrantly expressed in gastric cancer (GC) based on bioinformatics analysis. However, its function has not been studied in GC. Materials and Methods: The relation of SSC4D with GC patient survival and diagnsois was investigated based on bioinformatics analysis and clinical information from forty-seven patients. SSC4D was silenced by shRNAs and the impact of SSC4D silencing on GC cell proliferaton, migration, and invasion was analyzed. Xenograft nude mice were also used to reveal the function of SSC4D on GC carciogenesis at a pre-clinical level. Results: The knockdown of SSC4D inhibits GC cell malignacy as well as tumorigenesis. Conclusion: SSC4D exerts oncogenic effects on GC cell growth, migration, invasiveness and epithelial cell mesenchymal transition (EMT) and tumor growth.
Keywords: Gastric cancer, SSC4D, biomarker, migration, invasion.
Full-Text [PDF 1266 kb]   (158 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Zhou J, Jiang T, Qi Q. Long non-coding RNA SSC4D as a potential diagnostic biomarker promotes gastric cell proliferation and metastasis. Int J Radiat Res 2024; 22 (4) :963-970
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Volume 22, Issue 4 (10-2024) Back to browse issues page
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