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Long non-coding RNA SSC4D as a potential diagnostic biomarker promotes gastric cell proliferation and metastasis
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J. Zhou   , T. Jiang , Q. Qi |
| Department of Pediatric, Haining Traditional Chinese Medicine Hospital, Jiaxing, Zhejiang, 314400, China , qiqingqing2023@163.com |
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Abstract: (79 Views) |
Background: Scavenger receptor cysteine-rich family member with 4 domains (SSC4D) is aberrantly expressed in gastric cancer (GC) based on bioinformatics analysis. However, its function has not been studied in GC. Materials and Methods: The relation of SSC4D with GC patient survival and diagnsois was investigated based on bioinformatics analysis and clinical information from forty-seven patients. SSC4D was silenced by shRNAs and the impact of SSC4D silencing on GC cell proliferaton, migration, and invasion was analyzed. Xenograft nude mice were also used to reveal the function of SSC4D on GC carciogenesis at a pre-clinical level. Results: The knockdown of SSC4D inhibits GC cell malignacy as well as tumorigenesis. Conclusion: SSC4D exerts oncogenic effects on GC cell growth, migration, invasiveness and epithelial cell mesenchymal transition (EMT) and tumor growth. |
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| Keywords: Gastric cancer, SSC4D, biomarker, migration, invasion. |
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Full-Text [PDF 1266 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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