Background: It aimed to compare the efficacy of digital mammography and magnetic resonance imaging (MRI) used alone and in combination in the diagnosis of ductal carcinoma in situ (DCIS). Material and Methods: 78 patients with pathologically confirmed DCIS were enrolled in this retrospective study. All patients underwent digital mammography and MRI. The imaging results were graded using the Breast Imaging Reporting and Data System (BI-RADS), and the diagnostic sensitivity (Sen), specificity (Spe), and accuracy (Acc) of the two methods, both individually and in combination, were calculated. Results: imaging findings were classified as highly suspicious (BI-RADS grade 4 and above) or not highly suspicious (BI-RADS grade 3 and below). The Sen, Spe, and Acc of digital mammography in the diagnosis of DCIS were 68.97%, 60%, and 66.67%, respectively. The Sen, Spe, and Acc of MRI were 77.5%, 70%, and 75.64%, respectively. When the two techniques were combined, the Sen was increased to 87.93%, the Spe was 75%, and the Acc was 84.62%. There were visible distinctions in Sen and Acc between the combined use and single mammography detection (P<0.05). Conclusion: the combined use of digital mammography and MRI shows high Sen and Acc in the diagnosis of DCIS, which is more effective than single method. This article supports the use of multimodal diagnostic strategies in clinical practice to improve the diagnostic efficiency of DCIS.